Citation: Ming Zhao ZHU, Shao Bat LI, Qiang GAO, Guo Lin ZHANG. Synthesis of 1, 7-Bis(4-hydroxyphenyl)-3-hydroxy-1, 3-heptadien-5-one[J]. Chinese Chemical Letters, ;1999, 10(11): 917-918. shu

Synthesis of 1, 7-Bis(4-hydroxyphenyl)-3-hydroxy-1, 3-heptadien-5-one

1.
National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry Lanzhou University Lanzhou 730000;
2.
Laboratory of Materia Medica Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041

Received Date: 14 May 1999

A facile synthesis of the analog of curcumin, 1, 7-bis (4-hydroxyphenyl)-3-hydroxy-l, 3-heptadien-5-one 1 was achieved.The key step, was completed through the regioselective condensation of ketone 5 and acyl chloride 7.
- 1.7-Bis (4-hydroxyphenyl)-3-hydroxy-1.3-heptadien-5-one,
- regioselectivity,
- synthesis
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