Citation: Qun LIU, Bai Ling XU, Hong Wu ZHAO. STUDIES ON THE DEMETHYLATION-ALKYLATION REACTION OF ACETOPHENONES VIA 2-(1,3-DITHIAN-2-YLIDENE)-1-ARYLETHENONES[J]. Chinese Chemical Letters, ;1993, 4(4): 299-302. shu

STUDIES ON THE DEMETHYLATION-ALKYLATION REACTION OF ACETOPHENONES VIA 2-(1,3-DITHIAN-2-YLIDENE)-1-ARYLETHENONES

Department of Chemistry, Northeast Normal University, Changchun 130024

Received Date: 9 October 1992

2-(1,3-dithian-2-ylidene)-1-arylethenones 3 Via chemoselective 1,2-addition with methyl,ethyl,phenyl,allyl,and benzyl Grignard reagents afforded the corresponding alcohols (4).Catalyzing by silica gel,the alcohols 4 were converted to the aryl.ketones (5).The entire process represent a demethylation-alkylation reaction of acetophenones.The mechanism of reaction are proposed and the structure requirement for the conversion of the alcohols (4) was discussed.
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