Citation: Hai Hui XIE, Xiao Yi WEI, Ji Dong WANG, Mei Fang LIU, Ren Zhou YANG. A New Cytotoxic Acetogenin from the Seeds of Annona squamosa[J]. Chinese Chemical Letters, ;2003, 14(6): 588-590. shu

A New Cytotoxic Acetogenin from the Seeds of Annona squamosa

South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650

Received Date: 13 June 2002

Fund Project: This investigation was supported by a program No. KSCXI-09 from Chinese Academy of Sciences and a program No. 2KB04201S from Guangdong Provincial Department of Science and Technology. We thank Professor Bingfen XIE and Zongchao LIU, Cancer Institute, Sun Yet-sen University, for cytotoxicity testing.

new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparisonwith known compounds. It is the first example of Annonaceous acetogenin with each of the twoends of the aliphatic chain bearing a γ-lactone. The new compound exhibited cytotoxic activity invitro against bel-7402 and CNE₂ human tumor cell lines.
- Annona squamosa,
- Annona,
- acetogenins,
- squamostolide,
- cytotoxicity
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