Citation: Bao Gen WU, Wei Pin ZHEN, Yun Xin BO, Xu Chang HE, Dong Lu BAI. SYNTHESIS OF ANALOGUES OF HUPERZINE A 3．THE PREPARATION OF SOME SINGLE RING ANALOGUES OF HUPERZINE A[J]. Chinese Chemical Letters, ;1995, 6(3): 193-196. shu

SYNTHESIS OF ANALOGUES OF HUPERZINE A 3．THE PREPARATION OF SOME SINGLE RING ANALOGUES OF HUPERZINE A

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Tai-yuan Rood, Shanghai 200031

Received Date: 18 October 1994

Fund Project: This work was financially supported by a grant of National Natural Science Foundation of China. Authors are greatly indebted to Dr. X.C. Tang in Division of Pliannacology of the Institute for bio-assays.

Huperzine A(1),an inhibitor of acetylcholinesterase isolated from the clubmoss Huperzia serrata,is used for treatment of Alzheimer's disease.The preparation of four analogues of Hup A,compounds 2,3,4 and 5,was described.Their biological activities were also tested.
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