Citation:
Hui Ying LI, Kang Tai REN, Ru Yu CHEN. Novel Phosphonoacetic Acid Derivatives. Synthesis of N-(Ethoxycarbonylmethylphosphonyl)-α-Amino Esters and-α-Amino Phosphonic Acid Esters and Their Bioactivities[J]. Chinese Chemical Letters,
;1997, 8(12): 1047-1050.
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A series of novel phosphonoacetic acid derivatives,N-(ethoxycarbonylmethyl-ethoxyphosphonyl)-α-amino acid esters and α-amino phosphonates,were synthesized via the reaction of the corresponding phosphonyl chloride with amino acid ester hydrochlorides or amino phosphonates in the presence of a base.The preliminary bioassay shows that some compounds show significant anti-viral activity against tobacco mosaic virus (TMV).
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