Citation: Yong CHU, Ming Xia XU, Ding LU. Synthesis of Novel Antifungal Triazole Compounds[J]. Chinese Chemical Letters, ;2004, 15(9): 1011-1014. shu

Synthesis of Novel Antifungal Triazole Compounds

Yong CHU ^1, ,
Ming Xia XU ¹ ,
Ding LU ²

1.
Pharmacy School of West China, Sichuan University, Chengdu 610041;
2.
Sichuan Institute of Antibiotic Industry, Chengdu 610051

Received Date: 21 July 2003

Based on our previous studies of 3D-QSAR, 38 novel objective compounds belonging to 4 series were designed and successfully synthesized directed by the idea of reconstructing the structure of non-pharmacophores while reserving essential ones in triazoles. In vitro pilot studies on their antifungal activities showed that most compounds have inhibitory effects on C.albicans and some inhibit S.cerevisiae also. The effects on C.albicans of 5 compounds are more potent than or equal to that of fluconazole or itraconazole.
- Triazole,
- antifungal,
- synthesis,
- bioactivity
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