Citation: Jin Zong YOU, Shao Yuan CHEN, Yao Zu CHEN. The Synthesis of 6-Alkyl-5-Fluorouracil Derivatives[J]. Chinese Chemical Letters, ;2000, 11(11): 967-970. shu

The Synthesis of 6-Alkyl-5-Fluorouracil Derivatives

1.
Department of Chemistry, Zhejiang University, Hangzhou 310027;
2.
National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000

Received Date: 8 May 2000

6-alkyl-5-fluorouracil derivatives (5a~5f) were synthesized by facile alkylation of lithiation of 5-fluorouracil derivatives with mthyl iodide (MeI) or alkyl trifluoromethanesulfonate (ROTf) in yield of 42~58%. We found that the methylated product was ethyl-substituted derivatives, not methyl-substituted derivatives.
- Synthesis,
- alkylation,
- 6-alkyl-5-fluorouracil derivatives
1. [1]
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