Citation: Yi LUO, Ren Xi ZHUO, Chang Lie FAN. SYNTHESIS AND ANTITUMOR ACTIVITY OF PEPTIDYL-N¹-HYDROXYMETHYL-5-FLUOROURACIL[J]. Chinese Chemical Letters, ;1993, 4(7): 581-582. shu

SYNTHESIS AND ANTITUMOR ACTIVITY OF PEPTIDYL-N¹-HYDROXYMETHYL-5-FLUOROURACIL

Department of Chemistry, Wuhan University, Wuhan 430072

Received Date: 2 February 1993

Six hydrophobic peptidyl and four amino acid (L-Val, L-Leu,L-Phe, L-Gly) derivatives of 5-fluorouracil (5-FU) were synthesized.The structure of these compounds were characterized by ¹H-NMR, IR,UV spectra and elemental analysis.The antitumor activity was test-ed against EAC cells in vitro.
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