Citation: Tian-Cai Li, Cou-Xi Chen, Xue-Qiang Li, Xiao-Hui Gao. Selective amination of the mucohalic acid derivatives[J]. Chinese Chemical Letters, ;2013, 24(3): 202-204. shu

Selective amination of the mucohalic acid derivatives

1.
a School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China;
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b Ningxia Development Center of Natural Products and Medication, Ningxia University, Yinchuan 750021, China

Corresponding author: Xue-Qiang Li,
Received Date: 9 November 2012
Available Online: 5 January 2013

An efficient synthesis of 4,5-diamino-3-halofuran-2(5H)-ones has been developed based on a sequential acylation and bisamination of mucohalic acids. The β-and γ-amination products have also been prepared with high regioselectivity. This reaction shows some advantages in terms of its simple operation and readily available but highly functionalized starting material. All products gave satisfactory IR, ¹H NMR, ¹³C NMR and HRMS.
- 4,5-Diamino-3-halofuran-2(5H)-ones,
- 2(5H)-Furanones,
- Amine,
- Selective amination
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沈阳化工大学材料科学与工程学院沈阳 110142