Citation: Hemalatha Gadegoni, Sarangapani Manda. Synthesis and screening of some novel substituted indoles contained 1,3,4-oxadiazole and 1,2,4-triazole moiety[J]. Chinese Chemical Letters, ;2013, 24(2): 127-130. shu

Synthesis and screening of some novel substituted indoles contained 1,3,4-oxadiazole and 1,2,4-triazole moiety

Hemalatha Gadegoni ^a,, ,
Sarangapani Manda ^b

1.
a Jayamukhi College of Pharmacy, Narsampet, Warangal 506332, India;
2.
b University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India

Corresponding author: Hemalatha Gadegoni,
Received Date: 21 August 2012
Available Online: 20 December 2012

A series of novel 3-[5-(1H-indol-3-yl-methyl)-2-oxo-[1,3,4]oxadiazol-3-yl]propionitrile (5), 3-[4-amino-3-(1H-indol-3-yl-methyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]propionitrile (6), 3-[5-(1H-indol-3-yl-methyl)-2-thioxo-[1,3,4]oxadiazol-3-yl]propionitrile (7) and 3-[4-amino-3-(1H-indol-3-ylmethyl)-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]propionitrile (8) were synthesized in good yields from the intermediate (1H-indol-3-yl)-acetic acid N'-(2-cyanoethyl)hydrazide (4). The chemical structures of the newly synthesized compounds were elucidated by their IR, ¹H NMR and MS. Further, all the compounds were screened for their antimicrobial activity against Gram-positive, Gram-negative bacteria and also tested their ability toward anti-inflammatory activity.
- 1,3,4-Oxadiazols,
- 1,2,4-Triazols,
- Antimicrobial activity,
- Anti-inflammatory
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沈阳化工大学材料科学与工程学院沈阳 110142