Citation: Wu-Jiu JIANG, Yu-Jun TAN, Jia-Tai MAN, Yu-Xing TAN. Syntheses, Crystal Structures, Anticancer Activities and DNA-Binding Properties of the Dibutyltin Complexes Based on Benzoin Aroyl Hydrazone[J]. Chinese Journal of Structural Chemistry, ;2022, 41(2): 220210. doi: 10.14102/j.cnki.0254-5861.2011-3246 shu

Syntheses, Crystal Structures, Anticancer Activities and DNA-Binding Properties of the Dibutyltin Complexes Based on Benzoin Aroyl Hydrazone

a.
Key Laboratory of Functional Metal-organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China
b.
Emergency Department, Xiangya Hospital, Central South University, Changsha 410008, China

Corresponding author: Yu-Xing TAN, tanyuxing@hynu.edu.cn
Received Date: 6 May 2021
Accepted Date: 19 July 2021

Fund Project: the Scientific Research Fund of Hunan Provincial Education Department of China 19C0279

Figures(6)

Dibutyltin benzoin benzoyl hydrazone complex I [C₆H₅(O)C=N-N=C(Ph)CH(Ph)O]₂[(n-Bu)₂Sn]₂ and dibutyltin benzoin salicyl hydrazone complex II [2-(OH)-C₆H₄(O)C=N-N=C(Ph)CH(Ph)O]₂[(n-Bu)₂Sn]₂ were synthesized and characterized by IR, ¹H, ¹³C and ¹¹⁹Sn NMR spectra, HRMS, elemental analysis and thermal stability analysis, and the crystal structures were determined by X-ray diffraction. The crystal of complex I belongs to monoclinic system, space group P2₁/n with a = 11.1942(8), b = 10.4754(7), c = 23.6700(17) Å, β = 101.529(2)°, Z = 2, V = 2719.6(3) Å³, D_c = 1.371 Mg·m^–3, μ(MoKα) = 0.966 mm^–1, F(000) = 1152, R = 0.0458 and wR = 0.1312. The crystal of complex II is of triclinic system, space group P\begin{document}$ \overline 1 $\end{document} with a = 9.9960(4), b = 11.2466(4), c = 14.0509(5) Å, α = 69.4190(10)°, β = 70.0600(10)°, γ = 81.8090(10)°, Z = 1, V = 1389.69(9) Å³, D_c = 1.380 Mg·m^–3, μ(MoKα) = 0.950 mm^–1, F(000) = 592, R = 0.0284 and wR = 0.0690. In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines (MCF7, NCI-H460 and HepG2), and complex II exhibited better antitumor activity than I. The interaction between complexes and calf thymus DNA was studied by UV-vis, fluorescence spectroscopy and viscosity measurements.
- dibutyltin,
- complex,
- synthesis,
- crystal structure,
- DNA
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