Citation: Yun-Hong Yu, Yu Peng, Wei-Dong Z. Li. Highly fused tetracyclic diterpenoid natural products: Diverse biosynthesis and total synthesis[J]. Chinese Chemical Letters, ;2025, 36(10): 111137. doi: 10.1016/j.cclet.2025.111137 shu

Highly fused tetracyclic diterpenoid natural products: Diverse biosynthesis and total synthesis

School of Chemistry, Key Laboratory of Advanced Technologies of Material, Ministry of Education, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

pengyu@swjtu.edu.cn

wdli@swjtu.edu.cn

Received Date: 19 December 2024
Revised Date: 13 March 2025
Accepted Date: 23 March 2025
Available Online: 24 March 2025

Figures(29)

A category of highly fused diterpenoid natural products possessing a characteristic perhydropyrene-like or rearranged tetracyclic skeleton structure are distributed in different life forms. Compared to traditional polycyclic diterpenoids, their biosynthetic pathways are quite unique and diverse. Chemists have pinpointed a range of this type of unusual diterpenoids: cycloamphilectanes and isocycloamphilectanes, kempenes and rippertanes, hydropyrene and hydropyrenol, along with recently disclosed cephalotanes. This review describes developments in this field and discusses the challenges associated with synthesizing this class of highly complex compounds.
- Tetracyclic diterpenoid,
- Perhydropyrene skeleton,
- Natural products,
- Biosynthesis,
- Total synthesis,
- Cephalotanes
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