Citation: Yi-Ru Bai, Qing-Chuan Duan, Dong-Jie Seng, Ying Xu, Hong-Bo Ren, Jie Zhang, Dan-Dan Shen, Li Yang, Hong-Min Liu, Shuo Yuan. A comprehensive review of small molecule drugs approved by the FDA in 2024: Advance and prospect[J]. Chinese Chemical Letters, ;2025, 36(10): 111025. doi: 10.1016/j.cclet.2025.111025 shu

A comprehensive review of small molecule drugs approved by the FDA in 2024: Advance and prospect

Yi-Ru Bai ^{a, b, 1} ,
Qing-Chuan Duan ^{a, 1} ,
Dong-Jie Seng ^a ,
Ying Xu ^a ,
Hong-Bo Ren ^a ,
Jie Zhang ^a ,
Dan-Dan Shen ^c ,
Li Yang ^{c, *,} ,
Hong-Min Liu ^{b, *,} ,
Shuo Yuan ^{a, b, *,}

a.
Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou 450018, China
b.
School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou 450001, China
c.
Department of Obstetrics and Gynecology, Zhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment Zhengzhou China, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

zdsfyyangli@163.com

liuhm@zzu.edu.cn

zzuyuanshuo@163.com

Received Date: 7 December 2024
Revised Date: 25 February 2025
Accepted Date: 2 March 2025
Available Online: 7 March 2025

Figures(27)

In 2024, the U.S. Food and Drug Administration approved a total of 50 drug marketing applications, with small molecule drugs accounting for half of the medications. Upon surveying these endorsed pharmaceuticals, it becomes evident that certain structures exhibit familiarity, potentially resulting from structural modifications applied to previously approved drugs. Consequently, exploring the latest advancements in drug research not only aids comprehension of cutting-edge technologies used in drug development but also fosters invaluable experience and knowledge accumulation while nurturing innovative ideas for future drug discovery. This review comprehensively analyzes the research progress related to approved small molecule drugs, including aspects such as drug design, structural modification, activity enhancement, and druggability improvement. The aim is to provide valuable insights and assistance for researchers in pharmacology.
- Drug design,
- Mechanism of action,
- Molecular docking,
- Structure-activity relationship,
- Pharmacokinetic properties
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