Citation: Xinghao Cai, Chen Ma, Ying Kang, Yuqiang Ren, Xue Meng, Wei Lu, Shiming Fan, Shouxin Liu. Nickel-catalyzed C(sp²)–H alkynylation of free α-substituted benzylamines using a transient directing group[J]. Chinese Chemical Letters, ;2025, 36(10): 110901. doi: 10.1016/j.cclet.2025.110901 shu

Nickel-catalyzed C(sp²)–H alkynylation of free α-substituted benzylamines using a transient directing group

College of Chemical and Pharmaceutical Engineering, Hebei Collaborative Innovation Center of New Drug Creation, State Key Laboratory Breeding Base-Hebei Key Laboratory of Molecular Chemistry for Drug, Hebei University of Science & Technology, Shijiazhuang 050018, China

fanshiming1234@126.com

chsxliu@hotmail.com

Received Date: 17 October 2024
Revised Date: 19 January 2025
Accepted Date: 23 January 2025
Available Online: 25 January 2025

Figures(4)

A nickel-catalyzed C(sp²)–H alkynylation of unprotected α-substituted benzylamines is achieved by utilizing a transient directing group. The combination of a TDG with a nickel catalyst significantly improves the reaction step and atom economy. It has been investigated that the 2,4,6-trimethylpyridine ligand was critical to achieve the optimized reactivity. This protocol provides a straightforward route for synthesizing the alkynylated free benzylamines, featuring good substrate compatibility and monoselectivity.
- C–H activation,
- Nickel,
- Transient directing group,
- Amines,
- Alkynylation
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Nickel-catalyzed C(sp2)–H alkynylation of free α-substituted benzylamines using a transient directing group

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通讯作者: 陈斌, bchen63@163.com

Nickel-catalyzed C(sp²)–H alkynylation of free α-substituted benzylamines using a transient directing group