Citation: Wanxin Li, Wenxing Gao, Mengyao Wen, Zecheng He, Li Shang. Controllable synthesis of selenolate ligand-costabilized water-soluble near-infrared fluorescent gold nanoclusters for cell imaging[J]. Chinese Chemical Letters, ;2025, 36(10): 110803. doi: 10.1016/j.cclet.2024.110803 shu

Controllable synthesis of selenolate ligand-costabilized water-soluble near-infrared fluorescent gold nanoclusters for cell imaging

State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China

li.shang@nwpu.edu.cn

Received Date: 19 November 2024
Revised Date: 24 December 2024
Accepted Date: 25 December 2024
Available Online: 26 December 2024

Figures(6)

Selenolate ligands are expected to endow fluorescent gold nanoclusters (AuNCs) with better stability and more bioactivity than thiolate ligands, making them promising in the biological field. However, there are few studies on the synthesis of water-soluble selenolate-protected AuNCs, and the impact of selenolate ligands on the optical properties of AuNCs is still unclear. In this study, we synthesized selenolate-costabilized water-soluble, near-infrared fluorescent AuNCs with four different amounts of benzeneselenol (PhSeH), and systematically investigated the role of PhSeH on their optical properties. It is discovered that an appropriate PhSeH content is favorable for the fluorescence enhancement of AuNCs due to the ligand to metal charge transfer effect. Moreover, AuNCs co-stabilized by selenolate ligands exhibit better photostability and long-term stability compared with AuNCs stabilized by thiolate ligands, owing to the introduction of Au-Se bond on their surfaces. Further cellular experiments revealed that selenolate ligands can also affect the cellular uptake efficiency of AuNCs and their imaging property. These results provide important knowledges for further development of new, robust selenolate-stabilized metal NCs for biological application.
- Gold nanoclusters,
- Fluorescence probes,
- Surface ligands,
- Selenolate ligands,
- Cell imaging
1. [1]
  H.B. Lin, X.R. Song, O.J.H. Chai, et al., Adv. Mater. 36 (2024) 2401002. doi: 10.1002/adma.202401002
2. [2]
  R.R. Nasaruddin, T.K. Chen, N. Yan, J.P. Xie, Coord. Chem. Rev. 368 (2018) 60–79. doi: 10.1016/j.ccr.2018.04.016
3. [3]
  W.Q. Shi, L.L. Zeng, R.L. He, et al., Science 383 (2024) 326–330. doi: 10.1126/science.adk6628
4. [4]
  N.M. Carigga Gutierrez, T.L. Clainche, A.L. Bulin, et al., Adv. Mater. 36 (2024) 2404605. doi: 10.1002/adma.202404605
5. [5]
  M.J. Chao, S.M. Tai, M.X. Mao, et al., Aggregate 6 (2025) e644. doi: 10.1002/agt2.644
6. [6]
  X.D. Lai, T.F. Liu, Z.C. Guo, et al., Chin. Chem. Lett. 36 (2025) 109762. doi: 10.1016/j.cclet.2024.109762
7. [7]
  X.M. Zhou, X.J. Wang, L. Shang, Chin. Chem. Lett. 34 (2023) 108093. doi: 10.1016/j.cclet.2022.108093
8. [8]
  W.B. Tseng, C.H. Hsu, M. Madhu, C.Y. Lu, W.L. Tseng, Chem. Eng. J. 498 (2024) 155133. doi: 10.1016/j.cej.2024.155133
9. [9]
  J.Y. Sun, J.Y. Li, X. Li, et al., Chin. Chem. Lett. 34 (2023) 107891. doi: 10.1016/j.cclet.2022.107891
10. [10]
  B.H. Zhang, J.S. Chen, Y.T. Cao, O.J.H. Chai, J.P. Xie, Small 17 (2021) 2004381. doi: 10.1002/smll.202004381
11. [11]
  C.Y. Liu, Y. Pei, H. Sun, J. Ma, J. Am. Chem. Soc. 137 (2015) 15809–15816. doi: 10.1021/jacs.5b09466
12. [12]
  W.N. Dong, F.J. Zhang, T.T. Li, et al., J. Am. Chem. Soc. 146 (2024) 22180–22192. doi: 10.1021/jacs.4c01291
13. [13]
  X.K. Wan, J.Q. Wang, Z.A. Nan, Q.M. Wang, Sci. Adv. 3 (2017) e1701823. doi: 10.1126/sciadv.1701823
14. [14]
  A. Cirri, H.M. Hernández, C. Kmiotek, C.J. Johnson, Angew. Chem. Int. Ed. 58 (2019) 13818–13822. doi: 10.1002/anie.201907586
15. [15]
  X.F. Jiang, X.Y. Wang, C. Yao, et al., J. Phys. Chem. Lett. 10 (2019) 5237–5243. doi: 10.1021/acs.jpclett.9b02046
16. [16]
  H. Tang, Q.Z. Li, W.X. Yan, X.Y. Jiang, Angew. Chem. Int. Ed. 60 (2021) 13829–13834. doi: 10.1002/anie.202101609
17. [17]
  K.Y. Zheng, M.I. Setyawati, D.T. Leong, J.P. Xie, Chem. Mater. 30 (2018) 2800–2808. doi: 10.1021/acs.chemmater.8b00667
18. [18]
  D. Yang, Y.T. Wu, Z.T. Yuan, et al., Sci. China Chem. 67 (2024) 806–823. doi: 10.1007/s11426-023-1851-9
19. [19]
  X. Kang, M.Z. Zhu, Small 15 (2019) 1902703. doi: 10.1002/smll.201902703
20. [20]
  C.K. Yee, A. Ulman, J.D. Ruiz, et al., Langmuir 19 (2003) 9450–9458. doi: 10.1021/la020628i
21. [21]
  F.K. Huang, R.C. Horton, D.C. Myles, R.L. Garrell, Langmuir 14 (1998) 4802–4808. doi: 10.1021/la980263v
22. [22]
  Y.B. Song, T.T. Cao, H.J. Deng, et al., Sci. China Chem. 57 (2014) 1218–1224. doi: 10.1007/s11426-014-5071-5
23. [23]
  Y. Negishi, W. Kurashige, U. Kamimura, Langmuir 27 (2011) 12289–12292. doi: 10.1021/la203301p
24. [24]
  W. Kurashige, M. Yamaguchi, K. Nobusada, Y. Negishi, J. Phys. Chem. Lett. 3 (2012) 2649–2652. doi: 10.1021/jz301191t
25. [25]
  B. Hu, F.P. Kong, X.N. Gao, et al., Angew. Chem. Int. Ed. 57 (2018) 5306–5309. doi: 10.1002/anie.201712921
26. [26]
  B. Hu, R.R. Cheng, X.J. Liu, et al., Biomaterials 92 (2016) 81–89. doi: 10.1016/j.biomaterials.2016.03.030
27. [27]
  L.D. Geoffrion, T. Hesabizadeh, D. Medina-Cruz, et al., ACS Omega 5 (2020) 2660–2669. doi: 10.1021/acsomega.9b03172
28. [28]
  J.P. Wang, M.K. Chen, Z.Y. Zhang, L. Ma, T.F. Chen, Coord. Chem. Rev. 493 (2023) 215278. doi: 10.1016/j.ccr.2023.215278
29. [29]
  L. Wang, W.F. Zheng, X.J. Jiang, Chem. Commun. 56 (2020) 6664–6667. doi: 10.1039/d0cc02077j
30. [30]
  Q. Li, M. Zhou, W.Y. So, et al., J. Am. Chem. Soc. 141 (2019) 5314–5325. doi: 10.1021/jacs.8b13558
31. [31]
  J. Zheng, C. Zhou, M.X. Yu, J.B. Liu, Nanoscale 4 (2012) 4073–4082. doi: 10.1039/c2nr31192e
32. [32]
  Z.K. Wu, R.C. Jin, Nano Lett. 10 (2010) 2568–2573. doi: 10.1021/nl101225f
33. [33]
  J.M. Forward, D. Bohmann, J.P. Fackler, R.J. Staples, Inorg. Chem. 34 (1995) 6330–6336. doi: 10.1021/ic00129a019
34. [34]
  J. Xu, J.M. Li, W.C. Zhong, et al., Chin. Chem. Lett. 32 (2021) 2390–2394. doi: 10.1016/j.cclet.2021.02.037
35. [35]
  Z.N. Wu, Q.F. Yao, O.J.H. Chai, et al., Angew. Chem. Int. Ed. 59 (2020) 9934–9939. doi: 10.1002/anie.201916675
36. [36]
  L. Shang, F. Stockmar, N. Azadfar, G.U. Nienhaus, Angew. Chem. Int. Ed. 52 (2013) 11154–11157. doi: 10.1002/anie.201306366
37. [37]
  Y. Negishi, K. Nobusada, T. Tsukuda, J. Am. Chem. Soc. 127 (2005) 5261–5270. doi: 10.1021/ja042218h
38. [38]
  Q. Li, X.M. Zhou, L.L. Tan, L. Shang, Sens. Actuators B: Chem. 385 (2023) 133695. doi: 10.1016/j.snb.2023.133695
39. [39]
  J. Jiang, C.V. Conroy, M.M. Kvetny, et al., J. Phys. Chem. C 118 (2014) 20680–20687. doi: 10.1021/jp5060217
40. [40]
  D. Radomska, R. Czarnomysy, D. Radomski, K. Bielawski, Int. J. Mol. Sci. 22 (2021) 1009–1035. doi: 10.3390/ijms22031009
41. [41]
  S. Patil, A. Sandberg, E. Heckert, W. Self, S. Seal, Biomaterials 28 (2007) 4600–4607. doi: 10.1016/j.biomaterials.2007.07.029
42. [42]
  K.Q. Liang, W.C. Zhong, M.Y. Wei, L.L. Tan, L. Shang, Anal. Chem. 95 (2023) 8077–8087. doi: 10.1021/acs.analchem.3c01077
1. [1]
  Xu Qu , Pengzhao Wu , Kaixuan Duan , Guangwei Wang , Liang-Liang Gao , Yuan Guo , Jianjian Zhang , Donglei Shi . Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence. Chinese Chemical Letters, 2024, 35(12): 109681-. doi: 10.1016/j.cclet.2024.109681
2. [2]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
3. [3]
  Zhixue Liu , Haiqi Chen , Lijuan Guo , Xinyao Sun , Zhi-Yuan Zhang , Junyi Chen , Ming Dong , Chunju Li . Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging. Chinese Chemical Letters, 2024, 35(9): 109666-. doi: 10.1016/j.cclet.2024.109666
4. [4]
  Qian Ren , Xue Dai , Ran Cen , Yang Luo , Mingyang Li , Ziyun Zhang , Qinghong Bai , Zhu Tao , Xin Xiao . A cucurbit[8]uril-based supramolecular phosphorescent assembly: Cell imaging and sensing of amino acids in aqueous solution. Chinese Chemical Letters, 2024, 35(12): 110022-. doi: 10.1016/j.cclet.2024.110022
5. [5]
  Jia-Mei Qin , Xue Li , Wei Lang , Fu-Hao Zhang , Qian-Yong Cao . An AIEgen nano-assembly for simultaneous detection of ATP and H₂S. Chinese Chemical Letters, 2024, 35(6): 108925-. doi: 10.1016/j.cclet.2023.108925
6. [6]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862
7. [7]
  Brandon Bishop , Shaofeng Huang , Hongxuan Chen , Haijia Yu , Hai Long , Jingshi Shen , Wei Zhang . Artificial transmembrane channel constructed from shape-persistent covalent organic molecular cages capable of ion and small molecule transport. Chinese Chemical Letters, 2024, 35(11): 109966-. doi: 10.1016/j.cclet.2024.109966
8. [8]
  Wenya Jiang , Jianyu Wei , Kuan-Guan Liu . Atomically precise superatomic silver nanoclusters stabilized by O-donor ligands. Chinese Journal of Structural Chemistry, 2024, 43(9): 100371-100371. doi: 10.1016/j.cjsc.2024.100371
9. [9]
  Shuwen SUN , Gaofeng WANG . Two cadmium coordination polymers constructed by varying Ⅴ-shaped co-ligands: Syntheses, structures, and fluorescence properties. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 613-620. doi: 10.11862/CJIC.20230368
10. [10]
  Lingling Su , Qunyan Wu , Congzhi Wang , Jianhui Lan , Weiqun Shi . Theoretical design of polyazole based ligands for the separation of Am(Ⅲ)/Eu(Ⅲ). Chinese Chemical Letters, 2024, 35(8): 109402-. doi: 10.1016/j.cclet.2023.109402
11. [11]
  Zhenzhong MEI , Hongyu WANG , Xiuqi KANG , Yongliang SHAO , Jinzhong GU . Syntheses and catalytic performances of three coordination polymers with tetracarboxylate ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1795-1802. doi: 10.11862/CJIC.20240081
12. [12]
  Jiming XI , Yukang TENG , Rui ZHANG , Zhenzhong LU . Fluorescent coordination polymers based on anthracene-and pyrene-derivative ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 847-854. doi: 10.11862/CJIC.20240367
13. [13]
  Tianyu Sun , Zhoujun Dong , Paul Michael Malugulu , Tengfei Zhen , Lei Wang , Yao Chen , Haopeng Sun . Advances in design strategies and imaging applications of specific butyrylcholinesterase probes. Chinese Chemical Letters, 2025, 36(7): 110451-. doi: 10.1016/j.cclet.2024.110451
14. [14]
  Xiangdong Lai , Tengfei Liu , Zengchao Guo , Yihan Wang , Jiang Xiao , Qingxiu Xia , Xiaohui Liu , Hui Jiang , Xuemei Wang . In situ formed fluorescent gold nanoclusters inhibit hair follicle regeneration in oxidative stress microenvironment via suppressing NFκB signal pathway. Chinese Chemical Letters, 2025, 36(2): 109762-. doi: 10.1016/j.cclet.2024.109762
15. [15]
  Ting Li , Xinxin Zheng , Lejing Qu , Yuanyuan Ou , Sai Qiao , Xue Zhao , Yajun Zhang , Xinfeng Zhao , Qian Li . A chromatographic method for pursuing potential GPCR ligands with the capacity to characterize their intrinsic activities of regulating downstream signaling pathway. Chinese Chemical Letters, 2024, 35(10): 109792-. doi: 10.1016/j.cclet.2024.109792
16. [16]
  Hao Wang , Meng-Qi Pan , Ya-Fei Wang , Chao Chen , Jian Xu , Yuan-Yuan Gao , Chuan-Song Qi , Wei Li , Xian-He Bu . Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes. Chinese Chemical Letters, 2024, 35(10): 109581-. doi: 10.1016/j.cclet.2024.109581
17. [17]
  Yue Mao , Zhonghang Chen , Tiankai Sun , Wenyue Cui , Peng Cheng , Wei Shi . Luminescent coordination polymers with mixed carboxylate and triazole ligands for rapid detection of chloroprene metabolite. Chinese Journal of Structural Chemistry, 2024, 43(9): 100353-100353. doi: 10.1016/j.cjsc.2024.100353
18. [18]
  Hao Jiang , Yuan-Yuan He , Hai-Chao Liang , Meng-Jia Shang , Han-Han Lu , Chun-Hua Liu , Yin-Shan Meng , Tao Liu , Yuan-Yuan Zhu . Tuning lanthanide luminescence from bipyridine-bis(oxazoline/thiazoline) tetradentate ligands. Chinese Journal of Structural Chemistry, 2024, 43(9): 100354-100354. doi: 10.1016/j.cjsc.2024.100354
19. [19]
  Dongdong YANG , Jianhua XUE , Yuanyu YANG , Meixia WU , Yujia BAI , Zongxuan WANG , Qi MA . Design and synthesis of two coordination polymers for the rapid detection of ciprofloxacin based on triphenylpolycarboxylic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2466-2474. doi: 10.11862/CJIC.20240266
20. [20]
  Yan XU , Suzhi LI , Yan LI , Lushun FENG , Wentao SUN , Xinxing LI . Structure variation of cadmium naphthalene-diphosphonates with the changing rigidity of N-donor auxiliary ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 395-406. doi: 10.11862/CJIC.20240226

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(86)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142