Citation: Ruimiao Chang, Xinying Qu, Yuting Ye, Ying Qu, Bingyang Chu, Zhiyong Qian. Current advances in nanomedicine-based therapies for acute kidney injury[J]. Chinese Chemical Letters, ;2025, 36(10): 110802. doi: 10.1016/j.cclet.2024.110802 shu

Current advances in nanomedicine-based therapies for acute kidney injury

Ruimiao Chang ^{b, c, d, e, 1} ,
Xinying Qu ^{b, d, e, f, 1} ,
Yuting Ye ^{b, d, e, f} ,
Ying Qu ^a ,
Bingyang Chu ^{a, *,} ,
Zhiyong Qian ^{a, *,}

a.
Department of Hematology and Institute of Hematology and Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
c.
School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
d.
Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China
e.
Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan 030001, China
f.
Academy of Medical Sciences, Shanxi Medical University, Taiyuan 030001, China

chubingyang@126.com

anderson-qian@163.com

Received Date: 12 November 2024
Revised Date: 24 December 2024
Accepted Date: 25 December 2024
Available Online: 26 December 2024

Figures(6)

Acute kidney injury (AKI) is a prevalent clinical syndrome characterized by a rapid loss of renal filtration function, with high incidence and mortality rates that are steadily rising. AKI not only affects the short-term prognosis of patients but also considerably raises the risk of progression to chronic kidney disease and end-stage renal disease, making it a significant threat to human health. Nanomedicine offers innovative therapeutic strategies for AKI and shows considerable potential in its treatment. This review comprehensively summarizes the application of nanomedicines in AKI therapy, with a particular focus on recent advances in the development of antioxidant, anti-inflammatory, and combined nanomedicine-based therapies targeting oxidative stress and inflammation, two primary pathological features of AKI. Additionally, this review also summarizes recent progress in AKI model construction to facilitate a better understanding and investigation of AKI. Overall, the review provides insights into innovative nanomedicine application in the effective treatment of AKI, hoping to provide new ideas for the clinical treatment of AKI.
- Acute kidney injury,
- Experimental model,
- Oxidative stress,
- Inflammation,
- Nanomedicine
1. [1]
  C. Ronco, R. Bellomo, J.A. Kellum, Lancet 394 (2019) 1949–1964. doi: 10.1016/S0140-6736(19)32563-2
2. [2]
  M.E. Thomas, C. Blaine, A. Dawnay, et al., Kidney Int. 87 (2015) 62–73. doi: 10.1038/ki.2014.328
3. [3]
  E.A.J. Hoste, J.A. Kellum, N.M. Selby, et al., Nat. Rev. Nephrol. 14 (2018) 607–625. doi: 10.1038/s41581-018-0052-0
4. [4]
  W.R. Zhang, C.R. Parikh, Annu. Rev. Physiol. 81 (2019) 309–333. doi: 10.1146/annurev-physiol-020518-114605
5. [5]
  J.L. Alge, J.M. Arthur, Clin. J. Am. Soc. Nephrol. 10 (2015) 147–155. doi: 10.2215/CJN.12191213
6. [6]
  Z. Xiao, Q. Huang, Y. Yang, et al., Theranostics 12 (2022) 2963–2986. doi: 10.7150/thno.71064
7. [7]
  E. Tutunea-Fatan, S. Arumugarajah, R.S. Suri, et al., J. Am. Soc. Nephrol. 35 (2024) 795–808. doi: 10.1681/asn.0000000000000334
8. [8]
  J. Harty, Ulster Med. J. 83 (2014) 149–157.
9. [9]
  L.F. Liesenfeld, B. Wagner, H.C. Hillebrecht, et al., Ann. Surg. Oncol. 29 (2021) 139–151.
10. [10]
  X. Zeng, G.M. McMahon, S.M. Brunelli, et al., Clin. J. Am. Soc. Nephrol. 9 (2014) 12–20. doi: 10.2215/CJN.02730313
11. [11]
  Q. Chen, Y. Nan, Y. Yang, et al., Bioact. Mater. 22 (2023) 141–167.
12. [12]
  H.N. Geo, D.D. Murugan, Z. Chik, et al., J. Control. Release 343 (2022) 237–254. doi: 10.1016/j.jconrel.2022.01.033
13. [13]
  J.Q. Feng, X. Tian, R.G. Cao, et al., Chin. Chem. Lett. 35 (2024) 109657. doi: 10.1016/j.cclet.2024.109657
14. [14]
  Y. Santhosh Kumar, C. Gurudeva, G. Sridevi, et al., Nano Biomed. Eng. 16 (2024) 510–519. doi: 10.1007/s40042-024-01140-5
15. [15]
  Y. Zhao, M. Pu, Y. Wang, et al., J. Control. Release 336 (2021) 233–251. doi: 10.1016/j.jconrel.2021.06.026
16. [16]
  S. Fishbane, Clin. J. Am. Soc. Nephrol. 3 (2008) 281–287. doi: 10.2215/CJN.02590607
17. [17]
  Y. Liu, J. Shi, Nano Today 27 (2019) 146–177. doi: 10.1016/j.nantod.2019.05.008
18. [18]
  F. Oroojalian, F. Charbgoo, M. Hashemi, et al., J. Control. Release 321 (2020) 442–462. doi: 10.1016/j.jconrel.2020.02.027
19. [19]
  A. Zuk, J.V. Bonventre, Annu. Rev. Med. 67 (2016) 293–307. doi: 10.1146/annurev-med-050214-013407
20. [20]
  S.R. Gonsalez, A.L. Cortês, R.C. d. Silva, et al., Pharmacol. Ther. 200 (2019) 1–12. doi: 10.1016/j.pharmthera.2019.04.001
21. [21]
  B.B. Ratliff, W. Abdulmahdi, R. Pawar, et al., Antioxid. Redox Signal. 25 (2016) 119–146. doi: 10.1089/ars.2016.6665
22. [22]
  E. Birben, U.M. Sahiner, C. Sackesen, S. Erzurum, O. Kalayci, World Allergy Organ. J. 5 (2012) 9–19. doi: 10.1097/WOX.0b013e3182439613
23. [23]
  X. Zhang, E. Agborbesong, X. Li, Int. J. Mol. Sci. 22 (2021) 11253. doi: 10.3390/ijms222011253
24. [24]
  L.Y. Chang, Y.L. Chao, C.C. Chiu, et al., Int. J. Mol. Sci. 25 (2024) 1518. doi: 10.3390/ijms25031518
25. [25]
  R. Medzhitov, Cell 140 (2010) 771–776. doi: 10.1016/j.cell.2010.03.006
26. [26]
  P.G. Vallés, A.F. Gil Lorenzo, R.D. Garcia, et al., Int. J. Mol. Sci. 24 (2023) 1415–1436. doi: 10.3390/ijms24021415
27. [27]
  H. Lian, J. Wei, R. Zang, et al., Nat. Commun. 9 (2018) 3349. doi: 10.1038/s41467-018-05559-w
28. [28]
  P.S. Tucker, A.T. Scanlan, V.J. Dalbo, Oxid. Med. Cell. Longev. 2015 (2015) 806358.
29. [29]
  H.W. Schnaper, Adv. Chronic Kidney Dis. 24 (2017) 107–116. doi: 10.1053/j.ackd.2016.11.011
30. [30]
  N.A. Hukriede, D.E. Soranno, V. Sander, et al., Nat. Rev. Nephrol. 18 (2022) 277–293. doi: 10.1038/s41581-022-00539-2
31. [31]
  R. Chen, Z. Zeng, Y. Zhang, et al., FASEB J. 34 (2020) 8887–8901. doi: 10.1096/fj.202000274r
32. [32]
  S.M. Owji, E. Nikeghbal, S.M. Moosavi, Exp. Physiol. 103 (2018) 1390–1402. doi: 10.1113/ep087140
33. [33]
  D.S. Sauriyal, A.S. Jaggi, N. Singh, A. Muthuraman, Fundam. Clin. Pharmacol. 26 (2011) 347–355.
34. [34]
  M. Damianovich, I. Ziv, S.N. Heyman, et al., Eur. J. Nucl. Med. Mol. Imag. 33 (2006) 281–291. doi: 10.1007/s00259-005-1905-x
35. [35]
  R.A. Matthijsen, D. Huugen, N.T. Hoebers, et al., Am. J. Pathol. 171 (2007) 1743–1752. doi: 10.2353/ajpath.2007.070184
36. [36]
  Y. Fu, C. Tang, J. Cai, et al., Am. J. Physiol. Renal Physiol. 315 (2018) F1098–F1106. doi: 10.1152/ajprenal.00199.2018
37. [37]
  N.L. Clef, A. Verhulst, P.C. D'Haese, B.A. Vervaet, PLoS One 11 (2016) e0152153. doi: 10.1371/journal.pone.0152153
38. [38]
  M.A. Perazella, M.H. Rosner, Clin. J. Am. Soc. Nephrol. 17 (2022) 1220–1233. doi: 10.2215/cjn.11290821
39. [39]
  N. Pabla, Z. Dong, Kidney Int. 73 (2008) 994–1007. doi: 10.1038/sj.ki.5002786
40. [40]
  D.G. Moledina, M.A. Perazella, Clin. J. Am. Soc. Nephrol. 12 (2017) 2046–2049. doi: 10.2215/CJN.07630717
41. [41]
  S.G. Yarlagadda, M.A. Perazella, Expert Opin. Drug Saf. 7 (2008) 147–158. doi: 10.1517/14740338.7.2.147
42. [42]
  J.T. Poston, J.L. Koyner, BMJ 364 (2019) k4891. doi: 10.1136/bmj.k4891
43. [43]
  A. Havasi, S.C. Borkan, Kidney Int. 80 (2011) 29–40. doi: 10.1038/ki.2011.120
44. [44]
  A. Zarjou, A. Agarwal, J. Am. Soc. Nephrol. 22 (2011) 999–1006. doi: 10.1681/ASN.2010050484
45. [45]
  W.J. Hubbard, M. Choudhry, M.G. Schwacha, et al., Shock 24 (2005) 52–57. doi: 10.1097/01.shk.0000191414.94461.7e
46. [46]
  X. Ba, T. Ye, H. Shang, et al., ACS Appl. Mater. Interfaces 16 (2024) 12117–12148. doi: 10.1021/acsami.3c19308
47. [47]
  H. Dai, Q. Fan, C. Wang, Exploration 2 (2022) 20210157. doi: 10.1002/EXP.20210157
48. [48]
  J. Zuo, X. Gao, J. Xiao, Y. Cheng, Chin. Chem. Lett. 24 (2023) 107827. doi: 10.1016/j.cclet.2022.107827
49. [49]
  Z. Cao, J. Liu, X. Yang, Exploration 4 (2024) 20230037. doi: 10.1002/EXP.20230037
50. [50]
  Y. Yang, Y. Nan, Q. Chen, et al., J. Mater. Chem. B 11 (2023) 8081–8095. doi: 10.1039/d3tb00970j
51. [51]
  H. Yu, T. Lin, W. Chen, et al., Biomaterials 219 (2019) 119368. doi: 10.1016/j.biomaterials.2019.119368
52. [52]
  S. Mosleh-Shirazi, M. Abbasi, M. Shafiee, et al., Mater. Today Commun. 26 (2021) 102064. doi: 10.1016/j.mtcomm.2021.102064
53. [53]
  B. Du, M. Yu, J. Zheng, Nat. Rev. Mater. 3 (2018) 358–374. doi: 10.1038/s41578-018-0038-3
54. [54]
  N. Kamaly, J.C. He, D.A. Ausiello, O.C. Farokhzad, Nat. Rev. Nephrol. 12 (2016) 738–753. doi: 10.1038/nrneph.2016.156
55. [55]
  T. Liu, B. Xiao, F. Xiang, et al., Nat. Commun. 11 (2020) 2788. doi: 10.1038/s41467-020-16544-7
56. [56]
  S. Yao, D. Wu, X. Hu, et al., Acta Biomater. 173 (2024) 482–494. doi: 10.1016/j.actbio.2023.11.010
57. [57]
  J. Li, Q. Duan, X. Wei, J. Wu, Q. Yang, Small 18 (2022) 2204388. doi: 10.1002/smll.202204388
58. [58]
  J. Zhang, J. Yan, Y. Wang, et al., Chin. Chem. Lett. 35 (2024) 108434. doi: 10.1016/j.cclet.2023.108434
59. [59]
  Y.F. Lin, Y.H. Lee, Y.H. Hsu, et al., Nanomedicine 12 (2017) 2741–2756. doi: 10.2217/nnm-2017-0256
60. [60]
  Y. Kuang, S.X. Chen, H. Chen, Mater. Design 232 (2023) 112076. doi: 10.1016/j.matdes.2023.112076
61. [61]
  D. Liu, F. Jin, G. Shu, et al., Biomaterials 211 (2019) 57–67. doi: 10.1016/j.biomaterials.2019.04.034
62. [62]
  D. Liu, G. Shu, F. Jin, et al., Sci. Adv. 6 (2020) eabb7422. doi: 10.1126/sciadv.abb7422
63. [63]
  H. Guo, T. Lan, X. Lu, et al., J. Mater. Chem. B 12 (2024) 3063–3078. doi: 10.1039/d3tb02318d
64. [64]
  J. Kim, Y.M. Seok, K.J. Jung, K.M. Park, Am. J. Physiol. Renal Physiol. 297 (2009) F461–F470. doi: 10.1152/ajprenal.90735.2008
65. [65]
  G.S. Oh, H.J. Kim, J.H. Choi, et al., Kidney Int. 85 (2014) 547–560. doi: 10.1038/ki.2013.330
66. [66]
  L. Li, Y. Shen, Z. Tang, et al., Exploration 3 (2023) 20220148. doi: 10.1002/EXP.20220148
67. [67]
  A. Joorabloo, T. Liu, Exploration 4 (2024) 20230066. doi: 10.1002/EXP.20230066
68. [68]
  F. Manea, F.B. Houillon, L. Pasquato, P. Scrimin, Angew. Chem. Int. Ed. 43 (2004) 6165–6169. doi: 10.1002/anie.200460649
69. [69]
  Y. Dai, Y. Ding, L. Li, Chin. Chem. Lett. 32 (2021) 2715–2728. doi: 10.1016/j.cclet.2021.03.036
70. [70]
  J. He, Y. Hou, Z. Zhang, et al., Nano Biomed. Eng. 16 (2024) 28–47. doi: 10.26599/nbe.2024.9290053
71. [71]
  Z. Wang, X. Song, H. Huang, M. Chang, Y. Chen, MedComm Biomater. Appl. 2 (2023) e53.
72. [72]
  S. Li, Z. Chen, F. Yang, W. Yue, Chin. Chem. Lett. 35 (2024) 108793. doi: 10.1016/j.cclet.2023.108793
73. [73]
  Y. Wu, W. Chen, C. Wang, D. Xing, Chin. Chem. Lett. 35 (2024) 109096. doi: 10.1016/j.cclet.2023.109096
74. [74]
  Y. Li, J. Liu, Mater. Horiz. 8 (2021) 336–350. doi: 10.1039/D0MH01393E
75. [75]
  J. Sheng, Y. Wu, H. Ding, et al., Adv. Mater. 36 (2023) 2211210.
76. [76]
  Y.M. Narode, G.K. Sharma, Nano Biomed. Eng. 16 (2024) 276–284. doi: 10.26599/nbe.2024.9290068
77. [77]
  H. Lei, Z. Pei, C. Jiang, L. Cheng, Exploration 3 (2023) 20220001. doi: 10.1002/EXP.20220001
78. [78]
  A. Shekhar, S. Singh, K. Gupta, A.K. Rai. R.P. Tewari, Nano Biomed. Eng. 15 (2023) 191–198. doi: 10.26599/nbe.2023.9290023
79. [79]
  F. Imanparast, M. Doosti, M.A. Faramarzi, Nano Biomed. Eng. 7 (2015) 111–127.
80. [80]
  Q. Weng, H. Sun, C. Fang, et al., Nat. Commun. 12 (2021) 1436. doi: 10.1038/s41467-021-21714-2
81. [81]
  D.Y. Zhang, M.R. Younis, H. Liu, et al., Biomaterials 271 (2021) 120706. doi: 10.1016/j.biomaterials.2021.120706
82. [82]
  K. Wang, Y. Zhang, W. Mao, et al., Adv. Funct. Mater. 32 (2021) 2109221.
83. [83]
  D.Y. Zhang, H. Liu, K.S. Zhu, et al., J. Nanobiotechnol. 19 (2021) 266. doi: 10.1007/978-3-030-72795-6_21
84. [84]
  Z. Liu, L. Xie, K. Qiu, et al., ACS Appl. Mater. Interfaces 12 (2020) 31205–31216. doi: 10.1021/acsami.0c07886
85. [85]
  W. Jiang, X. Hou, Y. Qi, et al., Adv. Sci. 11 (2024) 2303901. doi: 10.1002/advs.202303901
86. [86]
  Y. Yang, Z. Mao, W. Huang, et al., Sci. Rep. 6 (2016) 35344. doi: 10.1038/srep35344
87. [87]
  C. Xu, X. Qu, NPG Asia Mater. 6 (2014) e90. doi: 10.1038/am.2013.88
88. [88]
  X. Gao, B. Wang, J. Li, et al., Adv. Healthc. Mater. 12 (2023) 2301691. doi: 10.1002/adhm.202301691
89. [89]
  X. Liu, H. Meng, View 2 (2021) 20200190. doi: 10.1002/VIW.20200190
90. [90]
  E.B. Mojzer, M.K. Hrnčič, M. Škerget, Ž. Knez, U. Bren, Molecules 21 (2016) 901. doi: 10.3390/molecules21070901
91. [91]
  H. Yuan, F. Wang, Z. Wang, et al., ACS Mater. Lett. 5 (2023) 2807–2819. doi: 10.1021/acsmaterialslett.3c00906
92. [92]
  R. Zhang, L. Cheng, Z. Dong, et al., Mater. Horiz. 8 (2021) 1314–1322. doi: 10.1039/d0mh00193g
93. [93]
  Z. Xu, Y. Zhu, M. Xie, et al., J. Nanobiotechnol. 21 (2023) 281. doi: 10.1109/icaml60083.2023.00060
94. [94]
  Y. Tu, G. Fan, N. Wu, et al., View 5 (2024) 20230056. doi: 10.1002/VIW.20230056
95. [95]
  D.Y. Zhang, H. Liu, T. He, et al., Small 17 (2021) 2005113. doi: 10.1002/smll.202005113
96. [96]
  J. Pan, T. Wu, L. Chen, et al., Nanoscale 16 (2024) 2955–2965. doi: 10.1039/d3nr05255a
97. [97]
  Q. Chen, X. Wang, C. Yuan, et al., Front. Bioeng. Biotechnol. 11 (2023) 1159989. doi: 10.3389/fbioe.2023.1159989
98. [98]
  L. Li, S. Nie, T. Du, et al., MedComm Biomater. Appl. 2 (2023) e37.
99. [99]
  Y. Xu, Q. Zhang, R. Chen, et al., J. Am. Chem. Soc. 144 (2022) 23522–23533. doi: 10.1021/jacs.2c10323
100. [100]
  Z. Wang, L. Wang, H. Zhao, Chin. Chem. Lett. 35 (2024) 109637. doi: 10.1016/j.cclet.2024.109637
101. [101]
  H. Zhu, J. Fan, C. Yang, J. Liu, B. Ding, Nano Biomed. Eng. 16 (2024) 331–344. doi: 10.26599/nbe.2024.9290096
102. [102]
  D. Jiang, Z. Ge, H.J. Im, et al., Nat. Biomed. Eng. 2 (2018) 865–877. doi: 10.1038/s41551-018-0317-8
103. [103]
  Q. Zhang, S. Lin, L. Wang, et al., Chem. Eng. J. 413 (2021) 127426. doi: 10.1016/j.cej.2020.127426
104. [104]
  Y. Lin, M. Zhao, L. Bai, et al., J. Ind. Eng. Chem. 97 (2021) 256–266. doi: 10.1016/j.jiec.2021.02.007
105. [105]
  C. Qian, Y. Zhang, X. Chen, et al., View 5 (2024) 20240003. doi: 10.1002/VIW.20240003
106. [106]
  X. Lou, J. Lu, C. Wang, et al., Chem. Eng. J. 466 (2023) 143227. doi: 10.1016/j.cej.2023.143227
107. [107]
  W. Xin, S. Gong, Y. Chen, et al., Adv. Health. Mater. 13 (2024) 2400441.
108. [108]
  Y. Liu, N. Feng, Adv. Colloid Interface Sci. 221 (2015) 60–76. doi: 10.1016/j.cis.2015.04.006
109. [109]
  H. Wei, D. Jiang, B. Yu, et al., Bioact. Mater. 19 (2023) 282–291.
110. [110]
  P. Yang, J. Zhang, S. Xiang, et al., ACS Appl. Mater. Interfaces 13 (2021) 39126–39134. doi: 10.1021/acsami.1c12176
111. [111]
  J. Zhang, X. Ren, Z. Nie, et al., J. Nanobiotechnol. 22 (2024) 626. doi: 10.1007/978-981-99-9315-4_61
112. [112]
  W. Feng, N. Zhu, Y. Xia, et al., iScience 27 (2024) 109504. doi: 10.1016/j.isci.2024.109504
113. [113]
  X. Zhang, L. Liang, F. Wang, et al., Adv. Sci. 11 (2024) 2402805. doi: 10.1002/advs.202402805
114. [114]
  Y. Wang, H. Fu, B. Huang, et al., Chem. Eng. J. 497 (2024) 155684. doi: 10.1016/j.cej.2024.155684
115. [115]
  S. Hong, H. Kim, J. Kim, et al., Cytotherapy 26 (2024) 51–62. doi: 10.1016/j.jcyt.2023.09.003
116. [116]
  Q. Qin, M. Wang, Y. Zou, et al., MedComm Biomater. Appl. 2 (2023) e65.
117. [117]
  S.J. Han, R.M. Williams, V. D'Agati, et al., Kidney Int. 98 (2020) 76–87. doi: 10.1016/j.kint.2020.01.036
118. [118]
  R. Han, Y. Xiao, Q. Bai, C.H.J. Choi, Acta Pharm. Sin. B 13 (2023) 1847–1865. doi: 10.1016/j.apsb.2022.07.009
119. [119]
  H. Liu, M. Ji, P. Xiao, et al., Asian J. Pharm. Sci. 19 (2024) 100922.
120. [120]
  I. Petta, L. Dejager, M. Ballegeer, et al., Microbiol. Mol. Biol. Rev. 80 (2016) 495–522. doi: 10.1128/MMBR.00064-15
121. [121]
  M. Oray, K.A. Samra, N. Ebrahimiadib, H. Meese, C.S. Foster, Expert Opin. Drug Saf. 15 (2016) 457–465. doi: 10.1517/14740338.2016.1140743
122. [122]
  C.M.A. van Alem, M. Boonstra, J. Prins, et al., Nephrol. Dial. Transplant. 33 (2018) 44–53. doi: 10.1093/ndt/gfx204
123. [123]
  H. Liu, H. Zhang, N. Yin, et al., Biomater. Sci. 8 (2020) 3871–3884. doi: 10.1039/d0bm00581a
124. [124]
  L. Guo, H. Wang, X. Liu, et al., ACS Appl. Mater. Interfaces 16 (2024) 59921–59933. doi: 10.1021/acsami.4c13481
125. [125]
  S. Wang, Y. Chen, S. Han, et al., Theranostics 12 (2022) 3882–3895. doi: 10.7150/thno.70830
126. [126]
  S.H. Hong, H.J. Lee, E.J. Sohn, et al., Pharmacol. Rep. 65 (2013) 970–979. doi: 10.1016/S1734-1140(13)71078-8
127. [127]
  J. Zhang, L. Gu, Y. Jiang, et al., Int. J. Nanomedicine 19 (2024) 1385–1408. doi: 10.2147/IJN.S444076
128. [128]
  W. Li, C. Wang, H. Lv, et al., ACS Nano 15 (2021) 18237–18249. doi: 10.1021/acsnano.1c07270
129. [129]
  Y. Fan, C. Wang, W. Dai, et al., ACS Appl. Mater. Interfaces 16 (2024) 38979–38988. doi: 10.1021/acsami.4c06110
130. [130]
  S. Liu, M. Zhao, Y. Zhou, et al., Acta Biomater. 103 (2020) 102–114. doi: 10.1016/j.actbio.2019.12.011
131. [131]
  R. Duan, Y. Li, R. Zhang, et al., Adv. Mater. 35 (2023) 2301283. doi: 10.1002/adma.202301283
132. [132]
  H. Bulluck, D.J. Hausenloy, Nat. Med. 24 (2018) 1306–1307. doi: 10.1038/s41591-018-0181-9
133. [133]
  K.M. Ralto, E.P. Rhee, S.M. Parikh, Nat. Rev. Nephrol. 16 (2019) 99–111.
134. [134]
  Y. Kong, X. Chen, F. Liu, et al., Adv. Mater. 36 (2024) 2310731. doi: 10.1002/adma.202310731
135. [135]
  S. Chen, J. Gao, T. Zhang, Asian J. Pharm. Sci. 19 (2024) 100942.
136. [136]
  B. Zhang, X. Tian, J. Hao, G. Xu, W. Zhang, Cell Transplant. 29 (2020) 0963689720908500. doi: 10.1177/0963689720908500
137. [137]
  Y. Hou, X. Zhang, D. Zeng, et al., View 5 (2024) 20240021. doi: 10.1002/VIW.20240021
138. [138]
  S. Song, L. Zhu, C. Wang, et al., View 4 (2022) 20220011. doi: 10.1002/VIW.20220011
139. [139]
  Y. Qu, B. Chu, J. Li, et al., Small Methods 8 (2024) 2301178. doi: 10.1002/smtd.202301178
140. [140]
  Y. Qu, B. Chu, X. Wei, et al., Adv. Mater. 34 (2022) 2107883. doi: 10.1002/adma.202107883
141. [141]
  Q. Hu, C.J. Lyon, J.K. Fletcher, et al., Acta Pharm. Sin. B 11 (2021) 1493–1512. doi: 10.1016/j.apsb.2020.12.014
142. [142]
  H. Ai, Y. Zou, X. Zheng, et al., View 5 (2024) 20240029. doi: 10.1002/VIW.20240029
143. [143]
  P. Fathi, L. Rao, X. Chen, View 2 (2021) 20200187. doi: 10.1002/VIW.20200187
144. [144]
  W. Zhou, X. Jiang, J. Gao, Asian J. Pharm. Sci. 19 (2024) 100965.
145. [145]
  M. Kosanović, B. Milutinovic, S. Glamočlija, et al., Int. J. Mol. Sci. 23 (2022) 3792. doi: 10.3390/ijms23073792
146. [146]
  K. Lv, T. Wu, S. Liu, et al., Acta Pharm. Sin. B 14 (2024) 4526–4543. doi: 10.1016/j.apsb.2024.06.027
147. [147]
  H. Kim, S.K. Lee, S. Hong, et al., Stem Cell Res. Ther. 15 (2024) 9. doi: 10.1186/s13287-023-03577-0
148. [148]
  Y. Zhou, S. Liu, M. Zhao, et al., J. Control. Release 316 (2019) 93–104. doi: 10.1016/j.jconrel.2019.11.003
149. [149]
  H. Huang, M. Qian, Y. Liu, et al., eLife 12 (2023) e84820. doi: 10.7554/eLife.84820
150. [150]
  F. Gao, B. Zuo, Y. Wang, et al., Life Sci. 255 (2020) 117719. doi: 10.1016/j.lfs.2020.117719
151. [151]
  Y. He, X. Li, B. Huang, et al., Shock 60 (2023) 419–426. doi: 10.1097/shk.0000000000002179
152. [152]
  Y. Li, C. Hu, P. Zhai, et al., Kidney Int. 105 (2024) 508–523. doi: 10.1016/j.kint.2023.12.007
153. [153]
  T. Tang, L. Lv, B. Wang, et al., Theranostics 9 (2019) 4740–4755. doi: 10.7150/thno.33520
154. [154]
  T. Tang, B. Wang, M. Wu, et al., Sci. Adv. 6 (2020) eaaz0748. doi: 10.1126/sciadv.aaz0748
155. [155]
  A. Macário-Soares, I. Sousa-Oliveira, M. Correia, et al., View 5 (2024) 20240043. doi: 10.1002/VIW.20240043
156. [156]
  R.H. Fang, W. Gao, L. Zhang, Nat. Rev. Clin. Oncol. 20 (2023) 33–48. doi: 10.1038/s41571-022-00699-x
157. [157]
  G. Zhou, W. Zhao, C. Zhang, et al., ACS Appl. Nano Mater. 5 (2022) 4130–4145. doi: 10.1021/acsanm.2c00071
158. [158]
  H. Maekawa, T. Inoue, H. Ouchi, et al., Cell Rep. 29 (2019) 1261–1273. doi: 10.1016/j.celrep.2019.09.050
159. [159]
  Y. Shen, F. Yang, F. Wu, et al., Nano Today 55 (2024) 102209. doi: 10.1016/j.nantod.2024.102209
160. [160]
  W. Ma, D. Wu, C. Long, et al., J. Control. Release 370 (2024) 66–81. doi: 10.1016/j.jconrel.2024.04.025
161. [161]
  R.L. Setten, J.J. Rossi, S. Han, Nat. Rev. Drug Discov. 18 (2019) 421–446. doi: 10.1038/s41573-019-0017-4
162. [162]
  B. Hu, L. Zhong, Y. Weng, et al., Signal Transduct. Target. Ther 5 (2020) 101. doi: 10.1038/s41392-020-0207-x
163. [163]
  A. Kumari, A. Kaur, G. Aggarwal, Asian J. Pharm. Sci. 18 (2023) 100845.
164. [164]
  H. Gao, R. Cheng, H.A. Santos, View 2 (2021) 20200111. doi: 10.1002/VIW.20200111
165. [165]
  G.W. Choi, J.H. Kim, D.W. Kang, et al., Eur. J. Pharm. Sci. 205 (2025) 106981. doi: 10.1016/j.ejps.2024.106981
166. [166]
  X. Bian, X. Yu, S. Lu, et al., Int. J. Biol. Macromol. 284 (2025) 137708. doi: 10.1016/j.ijbiomac.2024.137708
167. [167]
  W. Tang, S. Panja, C.M. Jogdeo, et al., Biomaterials 285 (2022) 121562. doi: 10.1016/j.biomaterials.2022.121562
168. [168]
  C.M. Jogdeo, S. Panja, N. Kumari, et al., J. Control. Release 376 (2024) 577–592. doi: 10.1016/j.jconrel.2024.10.027
169. [169]
  W. Tang, Y. Chen, H.S. Jang, et al., J. Control. Release 341 (2022) 300–313. doi: 10.1016/j.jconrel.2021.11.029
170. [170]
  X. Gu, K. Liu, Y. Deng, et al., Chem. Eng. J. 486 (2024) 150125. doi: 10.1016/j.cej.2024.150125
171. [171]
  T. Tang, B. Wang, Z. Li, et al., J. Am. Soc. Nephrol. 32 (2021) 2467–2483. doi: 10.1681/asn.2020111561
172. [172]
  Z. Li, X. Fan, J. Fan, et al., Nanomedicine 18 (2023) 1477–1493. doi: 10.2217/nnm-2023-0200
173. [173]
  D. Zhang, T. Tu, M.R. Younis, et al., Theranostics 11 (2021) 9904–9917. doi: 10.7150/thno.66518
174. [174]
  L. Zhou, S. Tang, F. Li, et al., Biomaterials 287 (2022) 121686. doi: 10.1016/j.biomaterials.2022.121686
175. [175]
  Y. Zheng, H. Yi, Z. Zhan, et al., J. Colloid Interface Sci. 662 (2024) 413–425. doi: 10.1016/j.jcis.2024.02.054
176. [176]
  J. Gu, P. Zhang, H. Li, et al., ACS Nano 18 (2024) 6229–6242. doi: 10.1021/acsnano.3c09528
177. [177]
  A.C. Bisen, A. Biswas, A. Dubey, et al., MedComm Biomater. Appl. 3 (2024) e77.
178. [178]
  Y. Yin, B. Hu, X. Yuan, et al., Pharmaceutics 12 (2020) 290. doi: 10.3390/pharmaceutics12030290
179. [179]
  J. Zhang, C. Wang, Y. Zhang, et al., Chin. Chem. Lett. 35 (2024) 109420. doi: 10.1016/j.cclet.2023.109420
180. [180]
  B. Du, M. Zhao, Y. Wang, et al., Eur. J. Pharmacol. 930 (2022) 175131. doi: 10.1016/j.ejphar.2022.175131
181. [181]
  Y. Li, G. Wang, T. Wang, et al., Nano Lett. 23 (2023) 5641–5647. doi: 10.1021/acs.nanolett.3c01235
182. [182]
  J. Zhou, M. Guan, H. Ma, et al., Nanomed. Nanotechnol. Biol. Med. 62 (2024) 102775. doi: 10.1016/j.nano.2024.102775
183. [183]
  J. Sun, X. Zhao, H. Shen, et al., J. Control. Release 368 (2024) 1–14. doi: 10.1016/j.jconrel.2024.02.021
184. [184]
  Z. Huang, C. Chun, X. Li, J. Control. Release 358 (2023) 368–381. doi: 10.1016/j.jconrel.2023.04.042
185. [185]
  Z. Liu, X. Liu, Q. Yang, et al., Acta Biomater. 104 (2020) 158–166. doi: 10.1016/j.actbio.2020.01.018
186. [186]
  R.L. Perlman, Evol. Med. Public Health (2016) 170–176.
187. [187]
  B. Packialakshmi, I.J. Stewart, D.M. Burmeister, K.K. Chung, X. Zhou, Ren. Fail. 42 (2020) 1042–1058. doi: 10.1080/0886022x.2020.1830108
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