Citation: Qing Zhang, Ling Sun, Lingyu Wu, Xue Wang, Liru Chen, Youyou Chen, Yuhang Liu, Wenhui Gu, Donglei Shi, Wenwen Liu, Jian Li, Yi-You Huang, Baoli Li, Hai-Bin Luo. Platycladus orientalis (L.) Franco demonstrates effective anti-psoriasis effects by inhibiting PDE4 with favorable safety profiles[J]. Chinese Chemical Letters, ;2025, 36(10): 110795. doi: 10.1016/j.cclet.2024.110795 shu

Platycladus orientalis (L.) Franco demonstrates effective anti-psoriasis effects by inhibiting PDE4 with favorable safety profiles

Qing Zhang ^{a, 1} ,
Ling Sun ^{a, 1} ,
Lingyu Wu ^{a, 1} ,
Xue Wang ^a ,
Liru Chen ^a ,
Youyou Chen ^a ,
Yuhang Liu ^a ,
Wenhui Gu ^a ,
Donglei Shi ^a ,
Wenwen Liu ^a ,
Jian Li ^{a, b, c} ,
Yi-You Huang ^{a, *,} ,
Baoli Li ^{a, *,} ,
Hai-Bin Luo ^{a, d, *,}

a.
Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China
b.
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
c.
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832003, China
d.
Song Li's Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Sanya 572000, China

hyyou@hainanu.edu.cn

baolili@hainanu.edu.cn

hbluo@hainanu.edu.cn

Received Date: 6 October 2024
Revised Date: 18 December 2024
Accepted Date: 22 December 2024
Available Online: 25 December 2024

Figures(6)

Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients. Phosphodiesterase-4 (PDE4) inhibitors have attracted significant interests in the psoriasis treatment due to their ability to suppress the inflammatory cascades. In this study, extensive screening of an in-house library of 1200 Chinese medicinal plant extracts identified Platycladus orientalis (L.) Franco (P. orientalis) as a potent PDE4 inhibitor, exhibiting 42.7% inhibition at 0.2 µg/mL. Subsequent bioassay-guided isolation revealed flavonoids, particularly amentoflavone (AMF), as the principal component responsible for PDE4 inhibition. To enrich the effective ingredients, a purification protocol using microporous resin was developed, yielding a flavonoid-rich extract (FLDs) that efficiently increased AMF content from 6.2% to 72.3% and improved PDE4 inhibitory activity to 74.2% at 0.2 µg/mL. Notably, P. orientalis with favorable safety profiles demonstrated superior in vitro and in vivo anti-psoriasis effects to both AMF and the approved PDE4 inhibitor apremilast. These findings highlight the potential of P. orientalis as a novel therapeutic agent for psoriasis and provide valuable insights for its development in psoriasis treatment.
- Platycladus orientalis (L.) Franco,
- Phosphodiesterase-4,
- Flavonoids,
- Psoriasis,
- Favorable safety
1. [1]
  M.A. Lowes, A.M. Bowcock, J.G. Krueger, Nature 445 (2007) 866–873. doi: 10.1038/nature05663
2. [2]
  X.J. Zhang, Chin. J. Dermatol. 56 (2023) 573–625. doi: 10.3390/fractalfract7080573
3. [3]
  Y. Duan, W. Sun, Y. Li, et al., Acta Pharm. Sin. B 14 (2024) 2646–2656. doi: 10.1016/j.apsb.2024.02.002
4. [4]
  R. Oliver, J. Krueger, S. Glatt, et al., Br. J. Dermatol. 186 (2022) 652–663. doi: 10.1111/bjd.20827
5. [5]
  S.Y. Paek, J. Frieder, D. Kivelevitch, et al., Semin. Cutaneous Med. Surg. 37 (2018) 148–157. doi: 10.12788/j.sder.2018.051
6. [6]
  A. Vu, C. Ulschmid, K.B. Gordon, Expert Opin. Biol. Ther. 22 (2022) 1489–1502. doi: 10.1080/14712598.2022.2132143
7. [7]
  M. Abramowicz, G. Zuccotti, J.M. Pflomm, J. Am. Med. Assoc. 318 (2017) 2487–2488. doi: 10.1001/jama.2017.18515
8. [8]
  D. Singh, Curr. Drug Ther. 19 (2024) 275–278. doi: 10.2174/0115748855274998231113110529
9. [9]
  J.E. Hawkes, M. Al-Saedy, N. Bouche, et al., Dermatol. Clin. 42 (2024) 365–375. doi: 10.1016/j.det.2024.02.006
10. [10]
  L.J. Scott, C.J. Dunn, K.L. Goa, Am. J. Clin. Dermatol. 2 (2001) 95–120. doi: 10.2165/00128071-200102020-00008
11. [11]
  G. Li, D. He, X. Cai, et al., Eur. J. Med. Chem. 250 (2023) 115195. doi: 10.1016/j.ejmech.2023.115195
12. [12]
  B.C. Du, M. Luo, C.Y. Ren, et al., Future Med. Chem. 15 (2023) 1185–1207. doi: 10.4155/fmc-2023-0101
13. [13]
  P.H. Schafer, F. Truzzi, A. Parton, et al., Cell. Signal. 28 (2016) 753–763. doi: 10.1016/j.cellsig.2016.01.007
14. [14]
  G.M. Keating, Drugs 77 (2017) 459–472. doi: 10.1007/s40265-017-0709-1
15. [15]
  E.L. Crowley, M.J. Gooderham, Pharmaceutics 16 (2023) 23. doi: 10.3390/pharmaceutics16010023
16. [16]
  P. Schafer, Biochem. Pharmacol. 83 (2012) 1583–1590. doi: 10.1016/j.bcp.2012.01.001
17. [17]
  D. Wu, X. Zheng, R. Liu, et al., Acta Pharm. Sin. B 12 (2022) 1351–1362. doi: 10.1016/j.apsb.2021.09.027
18. [18]
  Q. Zhou, M. Le, Y. Yang, et al., Acta Pharm. Sin. B 13 (2023) 1180–1191. doi: 10.1016/j.apsb.2022.09.023
19. [19]
  X.N. Wu, Q. Zhou, Y.D. Huang, et al., Acta Pharm. Sin. B 12 (2022) 3103–3112. doi: 10.1016/j.apsb.2022.02.012
20. [20]
  F.C. Meotti, F.C. Missau, J. Ferreira, et al., Biochem. Pharmacol. 72 (2006) 1707–1713. doi: 10.1016/j.bcp.2006.08.028
21. [21]
  M. Comalada, D. Camuesco, S. Sierra, et al., Eur. J. Immunol. 35 (2005) 584–592. doi: 10.1002/eji.200425778
22. [22]
  M. Kciuk, N. Garg, S. Dhankhar, et al., Pharmaceuticals 17 (2024) 701. doi: 10.3390/ph17060701
23. [23]
  S. Yu, H. Yan, L. Zhang, et al., Molecules 22 (2017) 299. doi: 10.3390/molecules22020299
24. [24]
  W. Huang, C. Liu, F. Liu, et al., Cell Biochem. Funct. 38 (2020) 249–256. doi: 10.1002/cbf.3443
25. [25]
  Z. Chen, Y. Shi, F. Zhong, et al., Chin. Chem. Lett. 36 (2025) 109956. doi: 10.1016/j.cclet.2024.109956
26. [26]
  X.Y. Lu, L. Kuai, F. Huang, et al., Nat. Commun. 14 (2023) 6767. doi: 10.1038/s41467-023-42477-y
1. [1]
  Zhexin Chen , Yuqing Shi , Fang Zhong , Kai Zhang , Furong Zhang , Shenghong Xie , Zhongbin Cheng , Qian Zhou , Yi-You Huang , Hai-Bin Luo . Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects. Chinese Chemical Letters, 2025, 36(4): 109956-. doi: 10.1016/j.cclet.2024.109956
2. [2]
  Xu Zhang , Jiang Li , Kai-Zhou Lu , Ya-Nan Yang , Jian-Shuang Jiang , Xiang Yuan , Zi-Ming Feng , Fei Ye , Pei-Cheng Zhang . Neosophoflavonoids A–C, A class of highly oxidized hybrid flavonoids from Sophora flavescens with antidiabetic effects. Chinese Chemical Letters, 2024, 35(10): 109456-. doi: 10.1016/j.cclet.2023.109456
3. [3]
  Yao Zou , Difei Gong , Haiguang Yang , Hongmei Yu , Guorong He , Ningbo Gong , Lianhua Fang , Guanhua Du , Yang Lu . Prediction, screening, characterization, antioxidant and antihypoxic effects of multi-component zwitterionic cocrystals of dietary flavonoids with picolinic acid. Chinese Chemical Letters, 2025, 36(9): 110768-. doi: 10.1016/j.cclet.2024.110768
4. [4]
  Yongjian Liu , Cen Liu , Haitao Guo , Jinchai Qi , Heng Chen , Yuping Yang , Tao Ma , Yonggang Liu . Alkaloids peganumiums A–C from Peganum harmala L., with two novel long conjugated structures. Chinese Chemical Letters, 2025, 36(8): 110558-. doi: 10.1016/j.cclet.2024.110558
5. [5]
  Xingyu Chen , Sihui Zhuang , Weiyao Yan , Zhengli Zeng , Jianguo Feng , Hongen Cao , Lei Yu . Synthesis, antibacterial evaluation, and safety assessment of Se@PLA as a potent bactericide against Xanthomonas oryzae pv. oryzae. Chinese Chemical Letters, 2024, 35(10): 109635-. doi: 10.1016/j.cclet.2024.109635
6. [6]
  Mei-Chen Liu , Qing-Song Liu , Yi-Zhou Quan , Jia-Ling Yu , Gang Wu , Xiu-Li Wang , Yu-Zhong Wang . Phosphorus-silicon-integrated electrolyte additive boosts cycling performance and safety of high-voltage lithium-ion batteries. Chinese Chemical Letters, 2024, 35(8): 109123-. doi: 10.1016/j.cclet.2023.109123
7. [7]
  Xiaofei NIU , Ke WANG , Fengyan SONG , Shuyan YU . Self-assembly of [Pd₆(L)₄]⁸⁺-type macrocyclic complexes for fluorescent sensing of HSO₃^-. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1233-1242. doi: 10.11862/CJIC.20240057
8. [8]
  Han Yuan , Fengcai Zhang , Hongzhe Huang , Jiafei Wu , Yi Yang , Wanyi Huang , Dongjing Yang , Zhuoming Li , Zhe Li , Ling Huang , Yi-You Huang , Hai-Bin Luo , Lei Guo . Discovery of 3-trifluoromethyl-substituted pyrazoles as selective phosphodiesterase 10A inhibitors for orally attenuating isoprenaline-induced cardiac hypertrophy. Chinese Chemical Letters, 2025, 36(4): 109965-. doi: 10.1016/j.cclet.2024.109965
9. [9]
  Yi Zhou , Wei Zhang , Rong Fu , Jiaxin Dong , Yuxuan Liu , Zihang Song , Han Han , Kang Cai . Self-assembly of two pairs of homochiral M₂L₄ coordination capsules with varied confined space using Tröger's base ligands. Chinese Chemical Letters, 2025, 36(2): 109865-. doi: 10.1016/j.cclet.2024.109865
10. [10]
  An Lu , Yuhao Guo , Yi Yan , Lin Zhai , Xiangyu Wang , Weiran Cao , Zijie Li , Zhixia Zhao , Yujie Shi , Yuanjun Zhu , Xiaoyan Liu , Huining He , Zhiyu Wang , Jian-Cheng Wang . Nanomedicine integrating the lipidic derivative of 5-fluorouracil, miriplatin and PD-L1 siRNA for enhancing tumor therapy. Chinese Chemical Letters, 2024, 35(6): 108928-. doi: 10.1016/j.cclet.2023.108928
11. [11]
  Liangyu Zhang , Lei Lei , Zhuangzhuang Zhao , Guizhi Yang , Kaitao Wang , Liying Wang , Ningxin Zhang , Yanjia Ai , Xinqing Ma , Guannan Liu , Meng Zhao , Jun Wu , Dongjun Lin , Chun Chen . Enhanced venetoclax delivery using l-phenylalanine nanocarriers in acute myeloid leukemia treatment. Chinese Chemical Letters, 2025, 36(6): 110316-. doi: 10.1016/j.cclet.2024.110316
12. [12]
  Ting Pan , Dinghu Zhang , Guomei You , Xiaoxia Wu , Chenguang Zhang , Xinyu Miao , Wenzhi Ren , Yiwei He , Lulu He , Yuanchuan Gong , Jie Lin , Aiguo Wu , Guoliang Shao . PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary. Chinese Chemical Letters, 2025, 36(1): 109857-. doi: 10.1016/j.cclet.2024.109857
13. [13]
  Hao Zhang , Haonan Qu , Ehsan Bahojb Noruzi , Haibing Li , Feng Liang . A nanocomposite film with layer-by-layer self-assembled gold nanospheres driven by cucurbit[7]uril for the selective transport of L-tryptophan and lysozyme. Chinese Chemical Letters, 2025, 36(1): 109731-. doi: 10.1016/j.cclet.2024.109731
14. [14]
  Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
15. [15]
  Yang Liu , Jing Liang , Mengzhu Zheng , Haoze Song , Lixia Chen , Hua Li . PD-L1/SHP2 dual PROTACs inhibit melanoma by enhancing T-cell killing activity. Chinese Chemical Letters, 2025, 36(6): 110317-. doi: 10.1016/j.cclet.2024.110317
16. [16]
  Ze Zhang , Lei Yang , Jin-Ru Liu , Hao Hu , Jian-Li Mi , Chao Su , Bei-Bei Xiao , Zhi-Min Ao . Improved oxygen electrocatalysis at FeN₄ and CoN₄ sites via construction of axial coordination. Chinese Chemical Letters, 2025, 36(2): 110013-. doi: 10.1016/j.cclet.2024.110013
17. [17]
  Kexin Yan , Zhaoqi Ye , Lingtao Kong , He Li , Xue Yang , Yahong Zhang , Hongbin Zhang , Yi Tang . Seed-Induced Synthesis of Disc-Cluster Zeolite L Mesocrystals with Ultrashort c-Axis: Morphology Control, Decoupled Mechanism, and Enhanced Adsorption. Acta Physico-Chimica Sinica, 2024, 40(9): 2308019-0. doi: 10.3866/PKU.WHXB202308019
18. [18]
  Xianchen Hu , Junli Yang , Fang Gao , Zhiyong Zhao , Simin Liu . Highly selective [4+4] cross-photodimerization of (4a-azonia)anthracenes driven by confinement of D-A hetero-guest pair in cucurbit[10]uril host. Chinese Chemical Letters, 2025, 36(3): 109967-. doi: 10.1016/j.cclet.2024.109967
19. [19]
  Yingxiao Zong , Yangfei Wei , Xiaoqing Liu , Junke Wang , Huanfang Guo , Junli Wang , Zhuangzhi Shi , Tao Tu , Cheng Yang , Chongyang Wang , Leyong Wang . The 4^th CCL Organic Chemistry Forum held in Zhangye. Chinese Chemical Letters, 2024, 35(8): 109743-. doi: 10.1016/j.cclet.2024.109743
20. [20]
  Yin-Hang Chai , Li-Long Dang . New structural breakthrough and topological transformation of homogeneous metalla[4]catenane compounds. Chinese Journal of Structural Chemistry, 2024, 43(10): 100322-100322. doi: 10.1016/j.cjsc.2024.100322

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(77)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142