Citation: Yihao He, Ru Guo, Lu Yang, Ling Li, Tong Zhang, Bing Wang, Yongzhuo Huang. Phospholipid complex-based microemulsion for treating concurrence of primary sclerosing cholangitis and inflammatory bowel disease via gut-liver crosstalk[J]. Chinese Chemical Letters, ;2025, 36(10): 110778. doi: 10.1016/j.cclet.2024.110778 shu

Phospholipid complex-based microemulsion for treating concurrence of primary sclerosing cholangitis and inflammatory bowel disease via gut-liver crosstalk

Yihao He ^{a, b} ,
Ru Guo ^{a, b} ,
Lu Yang ^d ,
Ling Li ^a ,
Tong Zhang ^{a, *,} ,
Bing Wang ^{b, *,} ,
Yongzhuo Huang ^{b, c, d, e, *,}

a.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
b.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China
c.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528437, China
d.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China
e.
NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Shanghai 201203, China

zhangtong@shutcm.edu.cn

bwang@simm.ac.cn

yzhuang@simm.ac.cn

Received Date: 16 June 2024
Revised Date: 16 December 2024
Accepted Date: 18 December 2024
Available Online: 20 December 2024

Figures(4)

The concurrence of primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) presents a therapeutic challenge, often necessitating liver transplantation in severe cases. Paeoniflorin (PAE), known for its immunomodulatory and anti-inflammatory properties but with very high-water solubility and low permeability, is formulated into a paeoniflorin/phospholipid complex microemulsion (PAE-ME) to enhance its delivery in this study. It demonstrated the PAE-ME's macrophage-regulating ability to repolarize the pro-inflammatory M1 subtype to the anti-inflammatory M2 type and reduce inflammatory cytokine release. In a PSC-IBD mouse model, PAE-ME alleviated the symptoms and regulated bile acid balance. Given the close connection and crosstalk between the liver and intestine, PAE-ME yielded a synergistic therapeutic effect on both the liver and intestinal lesions. These findings suggest a promising translational approach for complex comorbidities by acting on the liver-gut axis.
- Paeoniflorin,
- Phospholipid complex-based microemulsion,
- Primary sclerosing cholangitis,
- Inflammatory bowel disease,
- Macrophage regulation
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