Citation: Xinran Xi, Xiyu Wang, Ziyue Xi, Chuanyong Fan, Yingying Jiang, Zhenhua Li, Lu Xu. Facile GSH responsive glycyrrhetinic acid conjunction for liver targeting therapy[J]. Chinese Chemical Letters, ;2025, 36(10): 110773. doi: 10.1016/j.cclet.2024.110773 shu

Facile GSH responsive glycyrrhetinic acid conjunction for liver targeting therapy

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

xulu@syphu.edu.cn

Received Date: 11 June 2024
Revised Date: 15 December 2024
Accepted Date: 17 December 2024
Available Online: 18 December 2024

Figures(4)

Glycyrrhetinic acid (GA) sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver, however, the limitation of commonly used macromolecular GA modification approaches as well as the application gap across various vector have constrained its use. In this study, we proposed a novel perspective to break out, disulfide bonds (SS) were employed as linkage to facilitate GA modification, which allowed further connections with various carriers, while provided additional glutathione (GSH)-responsive property. The superiority of GA-disulfide conjunction was validated using mesoporous silica nanoparticles (MSN) as model carriers, chemotherapeutic drug (doxorubicin) and photosensitizer (indocyanine green) were loaded into MSN-SS-GA to further achieve chemo-photothermal synergistic anti-tumor therapy. Based on results from multiple evaluations, the GA-disulfide drafted MSN (DI/MSN-SS-GA) demonstrated expected liver tumor targeting effect and exhibited GSH-stimuli release property to reduce preleakage. Taken together, this study presents an effective chemo-photothermal therapy for liver cancer (88.26%), offers a potential, robust and straightforward strategy on GA application for enhancing liver targeting therapy.
- Glycyrrhetinic acid,
- Glutathione response,
- Liver targeting therapy,
- Mesoporous silica nanoparticles,
- Chemo-photothermal therapy
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