Citation: Mingrui Zhang, Lingyu Jin, Yuda Zhu, Junfeng Kou, Bo Liu, Jing Chen, Xiaolin Zhong, Xianghua Wu, Junfeng Zhang, Wenxiu Ren. A near-infrared Ⅱ fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor[J]. Chinese Chemical Letters, ;2025, 36(10): 110772. doi: 10.1016/j.cclet.2024.110772 shu

A near-infrared Ⅱ fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor

Mingrui Zhang ^{a, 1} ,
Lingyu Jin ^{b, 1} ,
Yuda Zhu ^b ,
Junfeng Kou ^a ,
Bo Liu ^a ,
Jing Chen ^b ,
Xiaolin Zhong ^c ,
Xianghua Wu ^{a, *,} ,
Junfeng Zhang ^{a, *,} ,
Wenxiu Ren ^{b, *,}

a.
Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China
b.
Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
c.
Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

chxhwu@sina.com

junfengzhang78@126.com

xrenwenxiux@swmu.edu.cn

Received Date: 7 October 2024
Revised Date: 12 December 2024
Accepted Date: 17 December 2024
Available Online: 18 December 2024

Figures(5)

The fluorophores Xan-OH and Xan-OH/FBS, based on xanthene structure, possess an effective near-infrared absorption, near-infrared Ⅱ (NIR-Ⅱ) fluorescent imaging ability, and excellent photothermal property. Xan-OH/FBS also has good viscosity-sensitivity, enabling the real-time in vivo visualization of acute liver injury induced by CCl₄. Moreover, the photothermal conversion coefficient of Xan-OH and Xan-OH/FBS under 808 nm laser irradiation are significant (27.53% and 26.77%, respectively), which could realize NIR-Ⅱ fluorescence imaging-guided photothermal therapy for HeLa xenograft tumor. Given these promising characteristics, Xan-OH/FBS is an efficient NIR-Ⅱ fluorescent imaging agent for acute liver injury and a potential photothermal therapeutic agent for tumor.
- Oxanthracene,
- NIR-Ⅱ fluorescent dye,
- NIR-Ⅱ fluorescent imaging,
- Acute liver injury,
- Photothermal therapy
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