Citation: Qiuxia Tan, E Pang, Qin Wang, Yuanyu Tang, Pan Zhu, Shaojing Zhao, Jianing Yi, Shiguang Jin, Minhuan Lan. Manganese carbonate-based nanoplatform for starvation therapy cascaded chemodynamic therapy, enhanced phototherapy and immune activation[J]. Chinese Chemical Letters, ;2025, 36(10): 110770. doi: 10.1016/j.cclet.2024.110770 shu

Manganese carbonate-based nanoplatform for starvation therapy cascaded chemodynamic therapy, enhanced phototherapy and immune activation

Qiuxia Tan ^{a, 1} ,
E Pang ^{a, 1} ,
Qin Wang ^a ,
Yuanyu Tang ^a ,
Pan Zhu ^a ,
Shaojing Zhao ^{a, *,} ,
Jianing Yi ^b ,
Shiguang Jin ^{c, *,} ,
Minhuan Lan ^{a, *,}

a.
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
b.
Department of Breast and Thyroid Gland Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, China
c.
Department of Central Laboratory, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou 225300, China

31180030@csu.edu.cn

jinshiguang20230419@njmu.edu.cn

minhuanlan@csu.edu.cn

Received Date: 7 October 2024
Revised Date: 15 December 2024
Accepted Date: 17 December 2024
Available Online: 18 December 2024

Figures(5)

Designing and synthesizing nanomedicines with multi-modal tumor therapeutic capabilities is the key to cancer treatment. Herein, we prepared MICG nanoparticles (NPs) by assembling glucose oxidase (GOx) and indocyanine green (ICG) with manganese carbonate (MnCO₃) NPs for starvation therapy cascaded chemodynamic therapy, enhanced phototherapy and immune activation. In MICG NPs, the GOx consumes intratumoral glucose resulting in starvation therapy, and simultaneously produces H₂O₂ and decreases pH in tumor. The intensified acidic tumor environment promotes the decomposition of MnCO₃ NPs to release Mn²⁺. The Mn²⁺ further catalyzes H₂O₂ to generate hydroxyl radical for chemodynamic therapy. While ICG can generate singlet oxygen (¹O₂) and heat to kill cancer cells through phototherapy mechanism. The hydroxyl radical and ¹O₂ will further accelerate the oxidative stress, intensify immunogenic cell death, induce dendritic cell maturation, and thus activate systemic immunity. This work provides a new therapeutic platform for combining therapy of tumor.
- Manganese carbonate,
- Phototherapy,
- Chemodynamic therapy,
- Starvation therapy,
- Immune activation
1. [1]
  S. Juengpanich, S. Li, T. Yang, et al., Nat. Commun. 14 (2023) 5699. doi: 10.1038/s41467-023-41389-1
2. [2]
  Z. Zhang, Z. Wei, J. Guo, et al., Nat. Commun. 15 (2024) 170. doi: 10.1038/s41467-023-43890-z
3. [3]
  X. Li, J.F. Lovell, J. Yoon, X. Chen, Nat. Rev. Clin. Oncol. 17 (2020) 657–674. doi: 10.1038/s41571-020-0410-2
4. [4]
  N. Kwon, H. Kim, X. Li, J. Yoon, Chem. Sci. 12 (2021) 7248–7268. doi: 10.1039/d1sc01125a
5. [5]
  S. Fu, Z. Chen, L. Li, et al., Coord. Chem. Rev. 507 (2024) 215734. doi: 10.1016/j.ccr.2024.215734
6. [6]
  L. Yu, M. Yu, W. Chen, et al., J. Am. Chem. Soc. 145 (2023) 8375–8388. doi: 10.1021/jacs.2c12986
7. [7]
  X. Wang, D. Chen, K. Huang, et al., Adv. Mater. 35 (2023) 2211055. doi: 10.1002/adma.202211055
8. [8]
  G. Ma, X. Zhang, K. Zhao, et al., ACS Nano 18 (2024) 3369–3381. doi: 10.1021/acsnano.3c10249
9. [9]
  Y. Zhao, X. Zhang, Y. Xu, et al., Angew. Chem. Int. Ed. 63 (2024) e202411514. doi: 10.1002/anie.202411514
10. [10]
  R. Wang, K. Kim, J. Yoo, et al., ACS Nano 16 (2022) 3045–3058. doi: 10.1021/acsnano.1c10565
11. [11]
  Y. Zhao, L. Zhang, Z. Chen, et al., J. Am. Chem. Soc. 143 (2021) 13980–13989. doi: 10.1021/jacs.1c07479
12. [12]
  S. Zeng, Y. Wang, C. Chen, et al., Angew. Chem. Int. Ed. 136 (2024) e202316487. doi: 10.1002/ange.202316487
13. [13]
  J. An, K. Lv, C.V. Chau, et al., J. Am. Chem. Soc. 146 (2024) 19434–19448. doi: 10.1021/jacs.4c05978
14. [14]
  Y. Huang, X. Wan, Q. Su, et al., Nat. Commun. 15 (2024) 1643. doi: 10.1038/s41467-024-45619-y
15. [15]
  P. Zhao, H. Li, W. Bu, Angew. Chem. Int. Ed. 62 (2023) e202210415. doi: 10.1002/anie.202210415
16. [16]
  Z. Tang, Q. He, J. Zhou, et al., Chin. Chem. Lett. 35 (2024) 109742. doi: 10.1016/j.cclet.2024.109742
17. [17]
  S. Sun, Q. Chen, Z. Tang, et al., Angew. Chem. Int. Ed. 59 (2020) 21041–21048. doi: 10.1002/anie.202007786
18. [18]
  J. Bao, R. Liu, Z. Yu, Z. Cheng, B. Chang, Adv. Funct. Mater. 34 (2024) 2316646. doi: 10.1002/adfm.202316646
19. [19]
  Z. Liu, S. Liu, B. Liu, et al., Chin. Chem. Lett. 35 (2024) 109626. doi: 10.1016/j.cclet.2024.109626
20. [20]
  D. Cen, Q. Zheng, B. Zheng, et al., Adv. Funct. Mater. 33 (2023) 2211402. doi: 10.1002/adfm.202211402
21. [21]
  K. Ling, J. Zheng, X. Jiang, et al., ACS Nano 18 (2024) 2841–2860. doi: 10.1021/acsnano.3c07123
22. [22]
  L. Lin, T. Huang, J. Song, et al., J. Am. Chem. Soc. 141 (2019) 9937–9945. doi: 10.1021/jacs.9b03457
23. [23]
  Y. Xiao, P. Chen, S. Lei, et al., Angew. Chem. Int. Ed. 61 (2022) e202204584. doi: 10.1002/anie.202204584
24. [24]
  X. Jia, J. Wang, E. Wang, Adv. Mater. 36 (2024) 2309261. doi: 10.1002/adma.202309261
25. [25]
  Y. Gao, Z. Ouyang, S. Shen, et al., ACS Nano 17 (2023) 23889–23902. doi: 10.1021/acsnano.3c08174
26. [26]
  Y. Bian, B. Liu, B. Ding, et al., Adv. Funct. Mater. 34 (2024) 2313853. doi: 10.1002/adfm.202313853
27. [27]
  H. Zhang, Y. Liu, Y. Cao, et al., Adv. Funct. Mater. 33 (2023) 2307175. doi: 10.1002/adfm.202307175
28. [28]
  H. Zhang, X. Pan, Q. Wu, et al., Exploration 1 (2021) 20210010. doi: 10.1002/EXP.20210010
29. [29]
  Y. Ma, Y. Zhao, N.K. Bejjanki, et al., ACS Nano 13 (2019) 8890–8902. doi: 10.1021/acsnano.9b02466
30. [30]
  H. Zhuang, X. He, H. Li, et al., ACS Nano 17 (2023) 13872–13884. doi: 10.1021/acsnano.3c03670
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  Xiaoyi Meng , Xinyue Sun , Zhaogang Sun , Yue Cheng , Yong Wang , Jun Ye , Yin Xiao , Hongqian Chu . Supramolecular-orchestrated carrier-free chemodynamic synergists with augmented oxidative damage for potentiated cancer therapy. Chinese Chemical Letters, 2025, 36(5): 110765-. doi: 10.1016/j.cclet.2024.110765
2. [2]
  Xueying Shi , Xiaoxuan Zhou , Bing Xiao , Hongxia Xu , Wei Zhang , Hongjie Hu , Shiqun Shao , Zhuxian Zhou , Youqing Shen , Xiaodan Xu , Jianbin Tang . A β-lapachone-loaded iron-polyphenol nanocomplex enhances chemodynamic therapy through cascade amplification of ROS in tumor. Chinese Chemical Letters, 2025, 36(5): 110178-. doi: 10.1016/j.cclet.2024.110178
3. [3]
  Zekun Gao , Xiuli Zheng , Weimin Liu , Jie Sha , Shuaishuai Bian , Haohui Ren , Jiasheng Wu , Wenjun Zhang , Chun-Sing Lee , Pengfei Wang . GSH-activatable copper-elsinochrome off-on photosensitizer for combined specific NIR-Ⅱ two-photon photodynamic/chemodynamic therapy. Chinese Chemical Letters, 2025, 36(3): 109874-. doi: 10.1016/j.cclet.2024.109874
4. [4]
  Zhiqiang Cui , Dongxiang Zhang , Yanru Huang , Chunyu Shao , Yiming Zhang , Changliang Sun , Xin-Dong Jiang , Xiaohong Sun , Qinghuan Xiao . Novel 1-phenylethyl-containing aza-BDOIPY for phototherapy and simultaneous monitoring of tumor immune microenvironment reprogramming. Chinese Chemical Letters, 2025, 36(7): 110460-. doi: 10.1016/j.cclet.2024.110460
5. [5]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
6. [6]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
7. [7]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
8. [8]
  Wenjuan Jin , Zelong Chen , Yi Wang , Jiaxuan Li , Jiahui Li , Yuxin Pei , Zhichao Pei . Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy. Chinese Chemical Letters, 2024, 35(7): 109328-. doi: 10.1016/j.cclet.2023.109328
9. [9]
  Ying Gao , Rong Zhou , Qiwen Wang , Shaolong Qi , Yuanyuan Lv , Shuang Liu , Jie Shen , Guocan Yu . Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy. Chinese Chemical Letters, 2024, 35(10): 109521-. doi: 10.1016/j.cclet.2024.109521
10. [10]
  Jin Wang , Xiaoyan Pan , Junyu Zhang , Qingqing Zhang , Yanchen Li , Weiwei Guo , Jie Zhang . Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy. Chinese Chemical Letters, 2024, 35(8): 109187-. doi: 10.1016/j.cclet.2023.109187
11. [11]
  Yingtao Zhong , Ziwen Qiu , Yanmei Li , Jiaqi Huang , Zhenming Lu , Renjiang Kong , Ni Yan , Hong Cheng . Nutrients deprivation of biomimetic nanozymes for cascade catalysis triggered and oxidative damage induced tumor eradication. Chinese Chemical Letters, 2025, 36(3): 109846-. doi: 10.1016/j.cclet.2024.109846
12. [12]
  Chanqi Ye , Jia Zhang , Jie Shen , Ruyin Chen , Qiong Li , Peng Zhao , Dong Chen , Jian Ruan . Attractive Pickering emulsion gel loaded with oxaliplatin and lactate dehydrogenase inhibitor increases the anti-tumor effect in hepatocellular carcinoma. Chinese Chemical Letters, 2025, 36(7): 110519-. doi: 10.1016/j.cclet.2024.110519
13. [13]
  Chenlu Huang , Xinyu Yang , Qingyu Yu , Linhua Zhang , Dunwan Zhu . Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680-. doi: 10.1016/j.cclet.2024.109680
14. [14]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
15. [15]
  Zhongyu Wang , Lijun Wang , Huaixin Zhao . DNA-based nanosystems to generate reactive oxygen species for nanomedicine. Chinese Chemical Letters, 2024, 35(11): 109637-. doi: 10.1016/j.cclet.2024.109637
16. [16]
  Yang Liu , Leilei Zhang , Kaixuan Liu , Ling-Ling Wu , Hai-Yu Hu . Penicillin G acylase-responsive near-infrared fluorescent probe: Unravelling biofilm regulation and combating bacterial infections. Chinese Chemical Letters, 2024, 35(11): 109759-. doi: 10.1016/j.cclet.2024.109759
17. [17]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
18. [18]
  Zhendong Liu , Sainan Liu , Bin Liu , Qi Meng , Meng Yuan , Chunzheng Yang , Yulong Bian , Ping'an Ma , Jun Lin . Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy. Chinese Chemical Letters, 2024, 35(11): 109626-. doi: 10.1016/j.cclet.2024.109626
19. [19]
  Yu-Hui Zhang , Ye Tian , Xianliang Sheng , Chen-Shuang Liu , Lu-Qiang Wei , Jie Wang , Yong Chen . Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110193-. doi: 10.1016/j.cclet.2024.110193
20. [20]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763

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