Citation: Xiying Wu, Anze Liu, Yuzhong Yan, Ying Lu, Huan Wang. Folic acid ameliorates the immunogenicity of PEGylated liposomes[J]. Chinese Chemical Letters, ;2025, 36(6): 110285. doi: 10.1016/j.cclet.2024.110285 shu

Folic acid ameliorates the immunogenicity of PEGylated liposomes

Xiying Wu ^a ,
Anze Liu ^b ,
Yuzhong Yan ^{c, *} ,
Ying Lu ^{b, *} ,
Huan Wang ^{b, *}

a.
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200433, China
b.
Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
c.
Department of Research and Discipline Development, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

zp_yanyz@sumhs.edu.cn

acuace@163.com

wang568855641@163.com

Received Date: 29 May 2024
Revised Date: 12 July 2024
Accepted Date: 18 July 2024
Available Online: 19 July 2024

Figures(4)

As PEGylated liposomes have witnessed remarkable advancements in drug delivery, their immunogenicity has emerged as a notable challenge. In this study, we discovered that a simple pre-injection of folic acid (FA) effectively mitigated the immunogenicity of PEGylated liposomes and enhanced their in vivo performance by tolerating splenic marginal zone B cells. FA specifically inhibited the internalization of PEGylated liposomes by splenic marginal zone B cells, thereby reducing splenic lymphocyte proliferation and specific IgM secretion. This modulation alleviated IgM-mediated accelerated blood clearance and adverse accumulation of the PEGylated liposomes in the skin. These findings provide new insights into the immunomodulatory effects of FA and promising avenues to enhance the efficacy and safety of PEGylated liposomal nanomedicines.
- Folic acid,
- Pegylated liposomes,
- Immunogenicity,
- Marginal zone B cells,
- Accelerated blood clearance
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