Citation: Xiaoshuai Wu, Bailei Wang, Yichen Li, Xiaoxuan Guan, Mingjing Yin, Wenquan Lv, Yin Chen, Fei Lu, Tao Qin, Huyang Gao, Weiqian Jin, Yifu Huang, Cuiping Li, Ming Gao, Junyu Lu. NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS[J]. Chinese Chemical Letters, ;2025, 36(2): 110211. doi: 10.1016/j.cclet.2024.110211 shu

NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

Xiaoshuai Wu ^{a, 1} ,
Bailei Wang ^{b, 1} ,
Yichen Li ^{c, 1} ,
Xiaoxuan Guan ^c ,
Mingjing Yin ^d ,
Wenquan Lv ^d ,
Yin Chen ^a ,
Fei Lu ^d ,
Tao Qin ^d ,
Huyang Gao ^c ,
Weiqian Jin ^c ,
Yifu Huang ^b ,
Cuiping Li ^{e, f, *,} ,
Ming Gao ^{c, *,} ,
Junyu Lu ^{a, *,}

a.
Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China
b.
Department of Critical Care Medicine, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, China
c.
Life Sciences Institute, Guangxi Medical University, Nanning 530021, China
d.
Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
e.
College & Hospital of Stomatology, Guangxi Medical University, Nanning 530021, China
f.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Medical University, Nanning 530021, China

gxcuiping@sina.com

gaoming1983125@hotmail.com

junyulu@gxmu.edu.cn

Received Date: 12 April 2024
Revised Date: 26 June 2024
Accepted Date: 3 July 2024
Available Online: 4 July 2024

Figures(3)

Acute lung injury (ALI) was characterized by excessive reactive oxygen species (ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme (P@Co) comprised of polydopamine (PDA) nanoparticles (NPs) loading with ultra-small Co, combining with near infrared (NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide (LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70 (HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.
- Acute lung injury,
- NIR driven,
- Nanozyme,
- ROS scavenging,
- M2 directional polarization
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