Citation: Xiao-Fang Lv, Xiao-Yun Ran, Yu Zhao, Rui-Rui Zhang, Li-Na Zhang, Jing Shi, Ji-Xuan Xu, Qing-Quan Kong, Xiao-Qi Yu, Kun Li. Combing NIR-Ⅱ molecular dye with magnetic nanoparticles for enhanced photothermal theranostics with a 95.6% photothermal conversion efficiency[J]. Chinese Chemical Letters, ;2025, 36(4): 110027. doi: 10.1016/j.cclet.2024.110027 shu

Combing NIR-Ⅱ molecular dye with magnetic nanoparticles for enhanced photothermal theranostics with a 95.6% photothermal conversion efficiency

Xiao-Fang Lv ^a ,
Xiao-Yun Ran ^a ,
Yu Zhao ^a ,
Rui-Rui Zhang ^a ,
Li-Na Zhang ^a ,
Jing Shi ^a ,
Ji-Xuan Xu ^b ,
Qing-Quan Kong ^{b, *,} ,
Xiao-Qi Yu ^c ,
Kun Li ^{a, *,}

a.
Key Laboratory of Green Chemistry Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
b.
Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region (Hospital C.T.), Sichuan University, Chengdu 610041, China
c.
Department of Chemistry, Xihua University, Chengdu 610039, China

kqqspine@126.com

kli@scu.edu.cn

Received Date: 3 April 2024
Revised Date: 14 May 2024
Accepted Date: 17 May 2024
Available Online: 19 May 2024

Figures(6)

Photoheranostics have emerged as a promising tool for cancer theranostics owing to their real-time feedback on treatment and their precise diagnosis. Among them, how to improve the photothermal conversion efficiency (PCE) of phototheranostic agents (PTAs) is the key factor for phototheranostic systems. Herein, we provided an efficient method to improve PCE and constructed a biocompatible nano-material ICR-Qu@NH₂-Fe₃O₄@PEG (QNFP) by combing near-infrared second region (NIR-Ⅱ) molecular dye ICR-Qu and amino-modified magnetic nanoparticles and then encapsulated by DSPE-mPEG2000. QNFP exhibited excellent performance for photothermal therapy with a high PCE of 95.6%. Both in vitro and in vivo experiments indicated that QNFP could inhibit the growth of tumors under laser irradiation with low toxicity and realized real-time NIR-Ⅱ fluorescent imaging of tumors. In general, we realized a simple but efficient method to improve the PCE of NIR-Ⅱ molecular dye without reduce its quantum yield, which is an ideal choice for cancer diagnosis and treatment.
- Photothermal therapy,
- Magnetic nanoparticles,
- NIR-Ⅱ fluorescence imaging,
- Photothermal conversion efficiency,
- NH₂-Fe₃O₄
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