Citation: Qian Ren, Xue Dai, Ran Cen, Yang Luo, Mingyang Li, Ziyun Zhang, Qinghong Bai, Zhu Tao, Xin Xiao. A cucurbit[8]uril-based supramolecular phosphorescent assembly: Cell imaging and sensing of amino acids in aqueous solution[J]. Chinese Chemical Letters, ;2024, 35(12): 110022. doi: 10.1016/j.cclet.2024.110022 shu

A cucurbit[8]uril-based supramolecular phosphorescent assembly: Cell imaging and sensing of amino acids in aqueous solution

Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Institute of Applied Chemistry, Guizhou University, Guiyang 550025, China

xxiao@gzu.edu.cn

Received Date: 9 February 2024
Revised Date: 1 May 2024
Accepted Date: 16 May 2024
Available Online: 17 May 2024

Figures(5)

In recent years, host-guest interactions of macrocycles have emerged as a promising approach to effectively enhance pure organic room-temperature phosphorescence by inhibiting the nonradiative relaxation while isolating the effects of oxygen and water molecules. In this work, a supramolecular assembly Q[8]-BCPI was constructed by 6-bromoisoquinoline derivative (BCPI) and cucurbit[8]uril (Q[8]). The assembly produced intense green room temperature phosphorescence (RTP) emission and enabled supramolecular recognition and detection of l-tryptophan (L-Trp) and l-tyrosine (L-Tyr). Moreover, the Q[8]-BCPI assembly showed good biocompatibility and low biotoxicity, and had a good staining effect on HeLa cells.
- Cucurbituril,
- Isobromoquinoline,
- Pure organic room-temperature phosphorescent,
- Cell imaging,
- Amino acid
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