Citation: Yueying Wang, Jianming Xiong, Linwei Xin, Yuanyuan Li, He Huang, Wenjun Miao. Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing[J]. Chinese Chemical Letters, ;2025, 36(4): 110003. doi: 10.1016/j.cclet.2024.110003 shu

Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing

Yueying Wang ^{a, 1} ,
Jianming Xiong ^{b, 1} ,
Linwei Xin ^a ,
Yuanyuan Li ^{c, *,} ,
He Huang ^{d, *,} ,
Wenjun Miao ^{b, e, *,}

a.
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
b.
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
c.
School of Pharmacy, Hainan Medical University, Haikou 571199, China
d.
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China
e.
State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China

liyuanyuan@hainmc.edu.cn

huangh@njnu.edu.cn

miaowj@njtech.edu.cn

Received Date: 14 March 2024
Revised Date: 6 May 2024
Accepted Date: 11 May 2024
Available Online: 12 May 2024

Figures(5)

The rapid emergence of drug-resistant bacterial strains undermines the efficacy of conventional antibiotics, necessitating the development of alternative therapies. Antimicrobial photodynamic therapy (PDT) is a promising approach, but its effectiveness is often limited by the suboptimal photocatalytic activity of photosensitizers. In this study, we introduce a novel photoresponsive carbon-based antibacterial agent, Ce6/g-C₃N₄, which combines the photocatalytic properties of graphite-phase carbon nitride (g-C₃N₄) with the photodynamic attributes of chlorin e6 (Ce6). This agent, with an average particle size of 250.7 nm, demonstrates significantly enhanced photocatalytic activity. Additionally, the strong affinity of Ce6/g-C₃N₄ for bacteria and efficient delivery of Ce6 result in an inhibition rate exceeding 99% against Gram-positive bacteria and excellent biofilm eradication under light irradiation. In vivo experiments reveal that Ce6/g-C₃N₄ effectively inhibits bacterial growth on wounds, and promotes wound healing post-light treatment, while maintaining good biocompatibility. Overall, the Ce6/g-C₃N₄ antibacterial agent synergizes photodynamic and photocatalytic mechanisms, offering a new avenue for the photo-mediated, multi-strategic treatment of bacterial infections and wound healing.
- Graphitic carbon nitride,
- Photosensitizer,
- Photocatalytic,
- Antibacterial,
- Photodynamic therapy
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