Citation: Tong Zhang, Xiaojing Liang, Licheng Wang, Shuai Wang, Xiaoxiao Liu, Yong Guo. An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography[J]. Chinese Chemical Letters, ;2025, 36(1): 109889. doi: 10.1016/j.cclet.2024.109889 shu

An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography

Tong Zhang ^{a, b} ,
Xiaojing Liang ^{a, *,} ,
Licheng Wang ^a ,
Shuai Wang ^a ,
Xiaoxiao Liu ^c ,
Yong Guo ^{a, *,}

a.
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Lanzhou Institute for Food and Drug Control, Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market Regulation, Lanzhou 730050, China

Received Date: 4 December 2023
Revised Date: 16 March 2024
Accepted Date: 14 April 2024
Available Online: 15 April 2024

Figures(7)

An ionic liquid assisted hydrogel modified silica was synthesized using a one-pot polymerization and physical coating technique and subsequently applied to mixed-mode liquid chromatography. Analytical techniques, including Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and elemental analysis, etc., confirmed the successful prepared of this innovative stationary phase. The unique combination of amide, long alkyl chain, and imidazole ring in the hydrogel coating enables the stationary phase to function effectively in hydrophilic/reversed-phase/ion exchange liquid chromatography. Notably, the stationary phase exhibited superior separation performance owing to the synergistic effect of the ionic liquid and hydrogel. This was particularly evident when analyzing various analytes such as organic acids, nucleosides/bases, polycyclic aromatic hydrocarbons (PAHs) and anions. Furthermore, under our operating conditions, an excellent column efficiency of 53, 642.9 plates/m was achieved for theobromine. In summary, we have proposed a straightforward strategy to enhance the separation performance of hydrogel coatings in liquid chromatography, thereby broadening the potential applications of hydrogels in the field of separation.
- Ionic liquid,
- Hydrogel,
- Functionalized silica,
- Synergistic effect,
- Stationary phase
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