Citation: Tong Tong, Lezong Chen, Siying Wu, Zhong Cao, Yuanbin Song, Jun Wu. Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment[J]. Chinese Chemical Letters, ;2024, 35(12): 109689. doi: 10.1016/j.cclet.2024.109689 shu

Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment

Tong Tong ^{a, 1} ,
Lezong Chen ^{b, 1} ,
Siying Wu ^{c, 1} ,
Zhong Cao ^{a, *,} ,
Yuanbin Song ^{b, *,} ,
Jun Wu ^{c, d, e, *,}

a.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518057, China
b.
Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
c.
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou 511400, China
d.
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR 999077, China
e.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

caozhong@mail.sysu.edu.cn

songyb@sysucc.org.cn

junwuhkust@ust.hk

Received Date: 2 February 2024
Revised Date: 27 February 2024
Accepted Date: 29 February 2024
Available Online: 2 March 2024

Figures(8)

Colorectal cancer is a common cancer worldwide. Traditional chemotherapeutic drugs often face limitations such as poor aqueous solubility and high systemic toxicity, which can lead to adverse side effects and limited therapeutic efficacy. In this study, a library of one kind of biodegradable and biocompatible polymer, leucine based-poly(ester amide)s (Leu-PEAs) was developed and utilized as drug carrier. The structure of Leu-PEAs can be tuned to alter their physicochemical properties, enhancing drug loading capacity and delivery efficiency. Leu-PEAs can self-assemble into nanoparticles by nanoprecipitation and load paclitaxel (PTX) with the diameter of ~108 nm and PTX loading capacity of ~8.5%. PTX-loaded Leu-PEAs nanoparticles (PTX@Leu-PEAs) demonstrated significant inhibition of CT26 cell growth in vitro. In vivo, these nanoparticles exhibited prolonged tumor accumulation and antitumor effects, with no observed toxicity to normal organs. Furthermore, blank Leu-PEAs nanoparticles also showed antitumor effects in vitro and in vivo, which may be attributed to the activation of the mammalian target of rapamycin (mTOR) pathway by leucine. Consequently, this biocompatible Leu-PEAs nano-drug delivery system shows potential as a promising strategy for colorectal cancer treatment, warranting further investigation.
- Leucine-based poly(ester amide)s,
- Structure-property,
- Nanoplatform,
- Drug delivery,
- Colorectal cancer
1. [1]
  R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, CA Cancer J. Clin. 71 (2021) 7–33. doi: 10.3322/caac.21654
2. [2]
  D.S. Shewach, R.D. Kuchta, Chem. Rev. 109 (2009) 2859–2861. doi: 10.1021/cr900208x
3. [3]
  H. Mao, Y. Xie, H. Ju, et al., ACS Appl. Mater. Interfaces 10 (2018) 33923–33935. doi: 10.1021/acsami.8b11159
4. [4]
  R. Mahmoudi, S.A. Mirahmadi-Babaheidri, H. Delaviz, et al., J. Biomater. Appl. 35 (2020) 743–753.
5. [5]
  X.R. You, Y. Kang, G. Hollett, et al., J. Mater. Chem. B 4 (2016) 7779–7792. doi: 10.1039/C6TB01925K
6. [6]
  N. Bertrand, J. Wu, X.Y. Xu, N. Kamaly, O.C. Farokhzad, Adv. Drug Deliv. Rev. 66 (2014) 2–25. doi: 10.1016/j.addr.2013.11.009
7. [7]
  F.M. Kievit, M.Q. Zhang, Adv. Mater. 23 (2011) 217–247.
8. [8]
  J. Wu, L.L. Zhao, X.D. Xu, et al., Angew. Chem. Int. Ed. 54 (2015) 9218–9223. doi: 10.1002/anie.201503863
9. [9]
  X.R. You, Z.P. Gu, J. Huang, et al., Acta Biomater. 74 (2018) 180–191. doi: 10.1016/j.actbio.2018.05.040
10. [10]
  Q.J. Yuan, J. Huang, C.H. Xian, ACS Appl. Mater. Interfaces 13 (2021) 2165–2178. doi: 10.1021/acsami.0c15133
11. [11]
  S.Y. Han, J. Wu, ACS Appl. Mater. Interfaces 14 (2022) 55944–55956. doi: 10.1021/acsami.2c16492
12. [12]
  H.H. Hu, Z. Zhang, Y.F. Fang, L. Chen, J. Wu, Chin. Chem. Lett. 34 (2023) 107953. doi: 10.1016/j.cclet.2022.107953
13. [13]
  X.R. You, L.Y. Wang, J.F. Zhang, et al., Chin. Chem. Lett. 34 (2023) 107720. doi: 10.1016/j.cclet.2022.07.063
14. [14]
  Z. Gao, J. Huang, Z.X. Xie et al., Biomater. Sci. 10 (2022) 5187–5196. doi: 10.1039/d2bm00697a
15. [15]
  Y.B. Meng, J. Wu, ACS Appl. Mater. Interfaces 13 (2021) 49658–49670. doi: 10.1021/acsami.1c13013
16. [16]
  Y.X. Zeng, X.Y. Zhang, D.J. Lin et al., J. Hematol. Oncol. 14 (2021) 189. doi: 10.1109/cloud53861.2021.00032
17. [17]
  J.W. Zhang, J.H. Yan, Y.N. Wang et al., Chin. Chem. Lett. 35(2024) 108434. doi: 10.1016/j.cclet.2023.108434
18. [18]
  M. Winnacker, B. Rieger, Polym. Chem. 7 (2016) 7039–7046. doi: 10.1039/C6PY01783E
19. [19]
  H.L. Sun, R. Cheng, C. Deng, et al., Biomacromolecules 16 (2015) 597–605. doi: 10.1021/bm501652d
20. [20]
  Q. Yin, J.M. Brameld, T. Parr, A.J. Murton, Amino Acids 52 (2020) 477–486. doi: 10.1007/s00726-020-02829-0
21. [21]
  B.H. Boehmer, P.R. Baker, L.D. Brown, S.R. Wesolowski, P.J. Rozance, J. Endocrinol. 247 (2020) 115–126. doi: 10.1530/joe-20-0243
22. [22]
  L.Y. Zhang, F.N. Li, Q.P. Guo, et al., Nutrients 12 (2020) 1299. doi: 10.3390/nu12051299
23. [23]
  J. Chen, Y.H. Ou, R. Luo, et al., Nature 596 (2021) 281–284. doi: 10.1038/s41586-021-03768-w
24. [24]
  X. Xu, J. Wang, T. Tong et al., Haematologica 107 (2022) 2344–2355. doi: 10.3324/haematol.2021.280290
25. [25]
  G.M. Xi, X.Y. Hu, B.L. Wu, et al., Cancer Lett. 307 (2011) 141–148. doi: 10.1016/j.canlet.2011.03.026
26. [26]
  Q. Zhang, S.H. Si, S. Schoen, et al., J. Exp. Clin. Cancer Res. 32 (2013) 99. doi: 10.1186/1756-9966-32-99
27. [27]
  C.Z. Li, X.R. You, X. Xu et al., Adv. Sci. 9 (2022) 2104134. doi: 10.1002/advs.202104134
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2. [2]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
3. [3]
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6. [6]
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7. [7]
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8. [8]
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9. [9]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
10. [10]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
11. [11]
  Mengwei Ye , Qingqing Xu , Huanhuan Jian , Yiduo Ding , Wenpeng Zhao , Chenxiao Wang , Junya Lu , Shuaipeng Feng , Siling Wang , Qinfu Zhao . Recent trends of biodegradable mesoporous silica based nanoplatforms for enhanced tumor theranostics. Chinese Chemical Letters, 2025, 36(6): 110221-. doi: 10.1016/j.cclet.2024.110221
12. [12]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
13. [13]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
14. [14]
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15. [15]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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