Citation: Yiyang Shen, Zhen Zhang, Ruyi Liang, Tongbo Wu. Unraveling the interplay of DNAzyme and interfacial factors for enhanced biosensing[J]. Chinese Chemical Letters, ;2024, 35(12): 109638. doi: 10.1016/j.cclet.2024.109638 shu

Unraveling the interplay of DNAzyme and interfacial factors for enhanced biosensing

Yiyang Shen ^{a, b, 1} ,
Zhen Zhang ^{a, 1,} ,
Ruyi Liang ^b ,
Tongbo Wu ^{b, *,}

a.
The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China
b.
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

zhangzhen9009@163.com

wutongbo@hust.edu.cn

Received Date: 27 December 2023
Revised Date: 5 February 2024
Accepted Date: 7 February 2024
Available Online: 12 February 2024

Figures(4)

Deoxyribozyme (DNAzyme) and its substrate hybridization are crucial for achieving desirable detection performance in the DNAzyme coupling nanomaterial biosensor system. However, interfacial factors such as electrostatic repulsion, steric hindrance, and nonspecific adsorption from gold nanoparticles make this hybridization process complicated and challenging. Moreover, the DNAzyme structure changes with different application purposes, which might affect the DNAzyme and substrate’s connection. Few studies have focused on the interplay of DNAzyme and interfacial factors in the biosensor field. In this work, three types of DNAzyme variants were designed, and their biosensor performance rules were studied and summarized with the synergistic effect of interfacial factors. Additionally, corresponding biosensor applications, such as multiple modulation functions and miRNA detections, were constructed based on the distinct principles of DNAzyme variants.
- DNAzyme,
- Gold nanoparticles,
- Interfacial factor,
- Multiple modulation functions,
- miRNA detection
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