Citation: Jiechen Liu, Xiaoguang Li, Ruiyang Xia, Yuqi Wang, Fenghe Zhang, Yongzhi Pang, Qing Li. Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy[J]. Chinese Chemical Letters, ;2024, 35(12): 109619. doi: 10.1016/j.cclet.2024.109619 shu

Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy

Jiechen Liu ^{a, b, c, 1} ,
Xiaoguang Li ^{d, 1} ,
Ruiyang Xia ^{a, b, c} ,
Yuqi Wang ^{a, b, c} ,
Fenghe Zhang ^{a, b, c} ,
Yongzhi Pang ^{e, *,} ,
Qing Li ^{a, b, c, *,}

a.
School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Ji’nan 250012, China
b.
China & Shandong Key Laboratory of Oral Tissue Regeneration, Ji’nan 250012, China
c.
China & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Ji’nan 250012, China
d.
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan 250021, China
e.
Department of Oral and Maxillofacial Surgery, Jinan Stomatology Hospital, Ji’nan 250001, China

pangyongzhisy@126.com

lq580202@sdu.edu.cn

Received Date: 10 January 2024
Revised Date: 4 February 2024
Accepted Date: 7 February 2024
Available Online: 10 February 2024

Figures(5)

Patients with oral squamous cell carcinoma (OSCC) encounter challenges in achieving efficient antitumor immunity, primarily due to the inherent pathophysiological characteristics of solid tumors affecting drug accumulation and penetration. Insufficient T-cells and immune escape induced by tumor-associated macrophages (TAMs) further exacerbate these issues. This study utilized M1 macrophage membrane-modified spatial dimension conversion drug delivery systems (SDDDSs) and introduced photosensitizers chlorophyll Pyro and the immune agonist R848. This innovative approach enhanced tumor targeting and accumulation by transforming stimulus-responsive size-reductive SDDDSs into smaller-sized iRGD-Pyro and R848 within the extracellular tumor microenvironment (TME). This facilitated effective drug penetration into deep tumor regions and cellular uptake. The synergistic treatment strategy for OSCC, combining photodynamic therapy (PDT) and tumor immunotherapy, induced tumor cell apoptosis, triggered immunogenic cell death (ICD), polarized TAMs towards the M1 phenotype, promoted sufficient T-cell infiltration, and resulted in significant therapeutic outcomes. This approach offers a promising avenue for future OSCC therapeutic interventions.
- OSCC,
- Immunotherapy,
- PDT,
- SDDDSs,
- Downsize
1. [1]
  G. Barillari, O. Melaiu, M. Gargari, et al., Int. J. Mol. Sci. 23 (2022) 8336. doi: 10.3390/ijms23158336
2. [2]
  J. Michot, C. Bigenwald, S. Champiat, et al., Eur. J. Cancer 54 (2016) 139–148. doi: 10.1016/j.ejca.2015.11.016
3. [3]
  S. Han, K. Huang, Z. Gu, et al., Nanoscale 12 (2020) 413–436. doi: 10.1039/C9NR08086D
4. [4]
  H.M. Kluger, C.R. Zito, G. Turcu, et al., Clin. Cancer Res. 23 (2017) 4270–4279. doi: 10.1158/1078-0432.CCR-16-3146
5. [5]
  A.I. Minchinton, I.F. Tannock, Nat. Rev. Cancer 6 (2006) 583–592. doi: 10.1038/nrc1893
6. [6]
  X. Xu, J. Wu, Y. Liu, et al., Angew. Chem. Int. Ed. 55 (2016) 7091–7094. doi: 10.1002/anie.201601273
7. [7]
  Y. Liu, D. Zhang, Z.Y. Qiao, et al., Adv. Mater. 27 (2015) 5034–5042. doi: 10.1002/adma.201501502
8. [8]
  K. Kessenbrock, V. Plaks, Z. Werb, Cell 141 (2010) 52–67. doi: 10.1016/j.cell.2010.03.015
9. [9]
  Y. Yuan, T. Nie, Y. Fang, et al., J. Mater. Chem. B 10 (2022) 2077–2096. doi: 10.1039/D1TB02683F
10. [10]
  Z. Li, W. Li, S. Jiang, et al., Chin. Chem. Lett. 34 (2023) 109150.
11. [11]
  Z. Hussain, M.A. Rahim, N. Jan, et al., J. Control. Release 335 (2021) 130–157. doi: 10.1016/j.jconrel.2021.05.018
12. [12]
  Q. Li, W. Fan, Y. Ling, et al., Mater. Design 227 (2023) 111777. doi: 10.1016/j.matdes.2023.111777
13. [13]
  X. Song, R. Qian, T. Li, et al., ACS Appl. Mater. Interfaces 14 (2022) 56548–56559. doi: 10.1021/acsami.2c16457
14. [14]
  H. He, L. Du, H. Xue, et al., Acta. Biomater. 149 (2022) 297–306. doi: 10.1016/j.actbio.2022.07.003
15. [15]
  X. Li, J.F. Lovell, J. Yoon, et al., Nat. Rev. Clin. Oncol. 17 (2020) 657–674. doi: 10.1038/s41571-020-0410-2
16. [16]
  S.Y. Li, H. Cheng, B.R. Xie, et al., ACS Nano 11 (2017) 7006–7018. doi: 10.1021/acsnano.7b02533
17. [17]
  H. Zhang, X. You, X. Wang, et al., Proc. Natl. Acad. Sci. U. S. A. 118 (2021) e2005191118. doi: 10.1073/pnas.2005191118
18. [18]
  Y. Yin, P. Sun, H. Dong, et al., Chin. Chem. Lett. 34 (2023) 108594. doi: 10.1016/j.cclet.2023.108594
19. [19]
  W.L. Liu, M.Z. Zou, T. Liu, et al., Nat. Commun. 10 (2019) 3199. doi: 10.1038/s41467-019-11157-1
20. [20]
  N.R. Anderson, N.G. Minutolo, S. Gill, et al., Cancer Res. 81 (2021) 1201–1208.
21. [21]
  A. Mantovani, F. Marchesi, A. Malesci, et al., Nat. Rev. Clin. Oncol. 14 (2017) 399–416. doi: 10.1038/nrclinonc.2016.217
1. [1]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
2. [2]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
3. [3]
  Shuang Liang , Jianjun Yao , Dan Liu , Mengli Zhou , Yong Cui , Zhaohui Wang . Tumor-responsive covalent organic polymeric nanoparticles enhancing STING activation for cancer immunotherapy. Chinese Chemical Letters, 2025, 36(3): 109856-. doi: 10.1016/j.cclet.2024.109856
4. [4]
  Yuequan Wang , Congtian Wu , Chengcheng Feng , Qin Chen , Zhonggui He , Shenwu Zhang , Cong Luo , Jin Sun . Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer. Chinese Chemical Letters, 2025, 36(3): 109902-. doi: 10.1016/j.cclet.2024.109902
5. [5]
  Yanjun Cai , Yong Jiang , Yu Chen , Erzhuo Cheng , Yuan Gu , Yuwei Li , Qianqian Liu , Jian Zhang , Jifang Liu , Shisong Han , Bin Yang . Amplifying STING activation and immunogenic cell death by metal-polyphenol coordinated nanomedicines for enhanced cancer immunotherapy. Chinese Chemical Letters, 2025, 36(5): 110437-. doi: 10.1016/j.cclet.2024.110437
6. [6]
  Chenlu Huang , Xinyu Yang , Qingyu Yu , Linhua Zhang , Dunwan Zhu . Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680-. doi: 10.1016/j.cclet.2024.109680
7. [7]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
8. [8]
  Xinyue Lan , Junguang Liang , Churan Wen , Xiaolong Quan , Huimin Lin , Qinqin Xu , Peixian Chen , Guangyu Yao , Dan Zhou , Meng Yu . Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy. Chinese Chemical Letters, 2024, 35(4): 108616-. doi: 10.1016/j.cclet.2023.108616
9. [9]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
10. [10]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
11. [11]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
12. [12]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
13. [13]
  Kun Chen , Huimin Lin , Xin Peng , Ziying Wu , Jingyue Dai , Yi Sun , Yaxuan Feng , Ziyi Huang , Zhiqiang Yu , Meng Yu , Guangyu Yao , Jigang Wang . In situ synthesis of MnO₂ micro/nano-adjuvants for enhanced immunotherapy of breast tumors. Chinese Chemical Letters, 2025, 36(5): 110045-. doi: 10.1016/j.cclet.2024.110045

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(425)
HTML views(13)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142