Citation: Zheyi Li, Xiaoyang Liang, Zitong Qiu, Zimeng Liu, Siyu Wang, Yue Zhou, Nan Li. Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel[J]. Chinese Chemical Letters, ;2024, 35(11): 109592. doi: 10.1016/j.cclet.2024.109592 shu

Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel

Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China

linan19850115@163.com

Received Date: 8 November 2023
Revised Date: 29 January 2024
Accepted Date: 31 January 2024
Available Online: 1 February 2024

Figures(4)

Melanoma treatment has been revolutionized with the development of targeted therapies and immunotherapies, which shows a positive influence on the patients. However, the long-term efficaciousness of such therapy is restricted by side effects, limited clinical effects as well as quick resistance to treatment. In this work, we prepared magnetocaloric carrier-free bimetallic hydrogels, named manganese-iron oxide nanocubes@polyethylene glycol-hydrogels (MFO@PEG-Gels), to realize ion-interferential cell cycle arrest for melanoma treatment. In detail, the tumor site was exposed to alternating magnetic field (AMF) after intratumorally injected MFO@PEG-Gels, which generated hyperthermia and promoted the sol-gel phase transition for MFO sustained release. Under the tumor microenvironment, hydrogen peroxide triggered MFO degradation to induce Mn²⁺ and Fe³⁺ release. On one hand, Mn²⁺ blocked G1/S phase through the activation of p27 pathway. On the other hand, Fe³⁺ could arrest the G2/M phase by upregulating the polo-like kinase 4 (PLK4) expression as well as inhibiting autolysosome formation to achieve the enhanced cell cycle arrest, thereby promoting the apoptosis of melanoma cells. In summary, this study proposed ion-interferential cell cycle arrest strategy by a multifunctional and injectable magnetic bimetallic hydrogel for melanoma treatment, which provided a secure and sustainable regimen for enhancing anti-tumor efficacy.
- Melanoma,
- Magnetocaloric bimetal,
- Sustained release hydrogel,
- Cell cycle arrest,
- Ion-interferential
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沈阳化工大学材料科学与工程学院沈阳 110142