Citation: Lei Wan, Yizhou Tong, Xi Lu, Yao Fu. Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp³) and C(sp)-C(sp²) bonds[J]. Chinese Chemical Letters, ;2024, 35(7): 109283. doi: 10.1016/j.cclet.2023.109283 shu

Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp³) and C(sp)-C(sp²) bonds

Lei Wan ^a ,
Yizhou Tong ^a ,
Xi Lu ^{b, *,} ,
Yao Fu ^{a, *,}

a.
Hefei National Research Center for Physical Sciences at the Microscale, iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, University of Science and Technology of China, Hefei 230026, China
b.
Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China

luxi@mail.ustc.edu.cn

fuyao@ustc.edu.cn

Received Date: 22 August 2023
Revised Date: 27 October 2023
Accepted Date: 6 November 2023
Available Online: 9 November 2023

Figures(6)

Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon–carbon bonds. Herein, we report a general method, cobalt-catalyzed reductive alkynylation, to construct C(sp)-C(sp³) and C(sp)-C(sp²) bonds. This presented reaction has a broad substrate scope, enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl (pseudo)halides. This presented reaction is conducted under mild conditions, tolerating many functional groups, thus suitable for the modification and synthesis of biologically active molecules.
- Cobalt-catalysis,
- Cross-electrophile coupling,
- Carbon–carbon bond formation,
- Reductive alkynylation,
- Alkyne synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142

Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp3) and C(sp)-C(sp2) bonds

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通讯作者: 陈斌, bchen63@163.com

Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp³) and C(sp)-C(sp²) bonds