Citation: Yifei Zhang, Yuncong Xue, Laiwei Gao, Rui Liao, Feng Wang, Fei Wang. Merging non-covalent and covalent crosslinking: En route to single chain nanoparticles[J]. Chinese Chemical Letters, ;2024, 35(6): 109217. doi: 10.1016/j.cclet.2023.109217 shu

Merging non-covalent and covalent crosslinking: En route to single chain nanoparticles

Yifei Zhang ^a ,
Yuncong Xue ^a ,
Laiwei Gao ^a ,
Rui Liao ^{a, b} ,
Feng Wang ^{a, *,} ,
Fei Wang ^{b, *,}

a.
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
b.
Department of Neurosurgical, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, Hefei 230026, China

drfwang@ustc.edu.cn

neurosurgeonwf1@ustc.edu.cn

Received Date: 6 September 2023
Revised Date: 12 October 2023
Accepted Date: 15 October 2023
Available Online: 17 October 2023

Figures(5)

Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's folding paradigm. Intrachain covalent crosslinking toward the formation of single-chain nanoparticles encounters complex energy landscapes, leading to the potential occurrence of misfolding issues. While non-covalent crosslinking can circumvent this issue, the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked counterparts. In this study, we present a novel approach for the synthesis of single-chain nanoparticles, achieved through the combination of non-covalent and covalent intramolecular crosslinking. Cyanostilbenes grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds, leading to the formation of non-covalently crosslinked single-chain nanoparticles. These nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using [2 + 2] photocycloaddition, a process facilitated by the supramolecular confinement effect. Consequently, the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability, offering significant potential for advancing applications across diverse fields.
- Single chain nanoparticles,
- Intrachain folding,
- Supramolecular confinement,
- Cyanostilbenes,
- [2 + 2] photocycloaddition
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