Citation: Wen Chen, Kun Shi, Yan Yu, Peipei Yang, Zhongwu Bei, Dong Mo, Liping Yuan, Meng Pan, Yu Chen, Zhiyong Qian. Drug delivery systems for colorectal cancer chemotherapy[J]. Chinese Chemical Letters, ;2024, 35(2): 109159. doi: 10.1016/j.cclet.2023.109159 shu

Drug delivery systems for colorectal cancer chemotherapy

Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

anderson-qian@163.com

zhiyongqian@scu.edu.cn

Received Date: 19 July 2023
Revised Date: 26 September 2023
Accepted Date: 27 September 2023
Available Online: 29 September 2023

Figures(9)

Colorectal cancer causes the third most common type of malignant tumors with high morbidity and mortality. Chemotherapy is currently one of the most effective and common treatments for colorectal cancer. However, the poor water solubility of some chemotherapeutics, untargeted drug delivery, and the undesirable systemic side effects of conventional treatment remain the major issues for colorectal cancer chemotherapy. Fortunately, drug delivery systems (DDS) based on biomaterials have been widely investigated and found to be capable of resolving those issues with good performance. Therefore, the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer chemotherapy. We not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics, including liposomes, micelles, and nanoparticles, but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus responses. Furthermore, locally administered systems based on hydrogels and microspheres, which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity, were also emphasized. DDS provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.
- Colorectal cancer,
- Chemotherapy,
- Drug delivery systems,
- Solubility,
- Targeted,
- Local administration
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