Citation: Yuanyi Zhou, Ke Ma, Jinfeng Liu, Zirun Zheng, Bo Hu, Yu Meng, Zhizhong Li, Mingshan Zhu. Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works[J]. Chinese Chemical Letters, ;2024, 35(6): 109056. doi: 10.1016/j.cclet.2023.109056 shu

Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works

Yuanyi Zhou ^{a, b, c, 1} ,
Ke Ma ^{d, 1} ,
Jinfeng Liu ^d ,
Zirun Zheng ^d ,
Bo Hu ^{a, b, d} ,
Yu Meng ^{a, b, d, *,} ,
Zhizhong Li ^{a, b, *,} ,
Mingshan Zhu ^{a, c, *,}

a.
Postdoctoral Innovation Practice Base, The First and Fifth Affiliated Hospital of Jinan University, Guangzhou 510632, China
b.
Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People’s Hospital), Heyuan 517465, China
c.
School of Environment, Jinan University, Guangzhou 511443, China
d.
Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China

mengy@jnu.edu.cn

tzzli@jnu.edu.cn

zhumingshan@jnu.edu.cn

Received Date: 29 June 2023
Revised Date: 31 August 2023
Accepted Date: 4 September 2023
Available Online: 10 September 2023

Figures(4)

Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species (ROS) modulation would boost the prosperity of nanomedicine in cancer treatment. Autophagy as a vital therapy target offers new options for the control of renal cell carcinoma (RCC) progression. Herein, Fe single atom-decorated graphene oxide (Fe₁-GO) nanosheet is developed to be a feasible autophagy inducer in RCC treatment. With the well-dispersed O−Fe₁−O active sites, Fe₁-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ones. In-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS generation. The in vivo therapeutic effect of Fe₁-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model, realizing an 89% reduction of tumor weight and good biosafety. This work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.
- Fe single atom,
- Autophagy,
- Renal cell carcinoma,
- Graphene oxide,
- Cancer therapy
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