Citation: Yuce Chen, Zhen Li, Yu Yin, Ping Yang, Yijin Kong, Zhong Li, Daijie Chen, Xiaoyong Xu. Identification of 2-aminothiazoyl piperidine derivatives as a new class of adjuvants potentiating the activity of colistin against Acinetobacter baumannii[J]. Chinese Chemical Letters, ;2023, 34(2): 107948. doi: 10.1016/j.cclet.2022.107948 shu

Identification of 2-aminothiazoyl piperidine derivatives as a new class of adjuvants potentiating the activity of colistin against Acinetobacter baumannii

Yuce Chen ^{a, 1} ,
Zhen Li ^{b, 1} ,
Yu Yin ^b ,
Ping Yang ^b ,
Yijin Kong ^a ,
Zhong Li ^{a, *,} ,
Daijie Chen ^{b, *,} ,
Xiaoyong Xu ^{a, *,}

a.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
b.
School of Pharmacy, Shanghai JiaoTong University, Shanghai 200240, China

lizhong@ecust.edu.cn

cdj@sjtu.edu.cn

xyxu@ecust.edu.cn

Received Date: 22 August 2022
Revised Date: 17 October 2022
Accepted Date: 23 October 2022
Available Online: 26 October 2022

Figures(8)

The rapid prevalence of antibiotic resistance has led to a significant global health problem. Although colistin is the last resort antibiotic, it is limited by dose dependent toxicity. A critical approach to solve this problem is to use an antibiotic adjuvant, which is able to potentiate the activity of antibiotic and reduce the dosage of antibiotic. Herein, we reported a novel 2-aminothiazoyl piperidine adjuvant, which enhanced the activity of colistin against Acinetobacter baumannii (A. baumannii). Two pilot libraries of 40 compounds were prepared and their adjuvant activities were evaluated. The most potential compound 11j enabled to cause16-fold reduction in the minimum inhibitory concentration (MIC) of colistin at 8 µg/mL. Besides, time-kill curves exhibited that compound 11j had significant adjuvant activity to kill the bacteria. The predicted ADMET analysis showed that 2-aminothiazoyl piperidine derivatives had good drug-likeness and acceptable physicochemical properties. Furthermore, membrane permeability experiments demonstrated that compound 11j was beneficial for colistin to destroy the outer membrane of bacteria. Also, the comparative molecular similarity indices analysis (CoMSIA) and the density functional theory (DFT) calculations were conducted. The results drawn from these analyses indicated that the novel scaffold provided helpful information for the finding of new adjuvant lead.
- 2-Aminothiazole piperidine,
- Antibiotic adjuvant,
- Acinetobacter baumannii,
- Colistin
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