Citation: Chao Yang, Dan Li, Shaohong Zang, Yingtang Zhou, Lei Zhang, Zhangfeng Zhong. Nanocoating of CsgA protein for enhanced cell adhesion and proliferation[J]. Chinese Chemical Letters, ;2023, 34(4): 107733. doi: 10.1016/j.cclet.2022.08.013 shu

Nanocoating of CsgA protein for enhanced cell adhesion and proliferation

Chao Yang ^{a, 1} ,
Dan Li ^{b, 1} ,
Shaohong Zang ^a ,
Yingtang Zhou ^a ,
Lei Zhang ^{c, *,} ,
Zhangfeng Zhong ^{d, *,}

a.
National Engineering Research Center for Marine Aquaculture, Institute of Innovation & Application, Zhejiang Ocean University, Zhoushan 316022, China
b.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
c.
Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L3G1, Canada
d.
Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China

l78zhang@uwaterloo.ca

zhangfengzhong@um.edu.mo

Received Date: 8 June 2022
Revised Date: 31 July 2022
Accepted Date: 8 August 2022
Available Online: 10 August 2022

Figures(4)

Immune rejection, poor biocompatibility and cytotoxicity have seriously stalled the widespread application of biometallic materials. To overcome these problems, biometallic materials with fast and sufficient osseointegration, antibacterial properties and long-term stability have attracted the attention of researchers worldwide. Surface modification is currently used as a general strategy to develop material coatings that will overcome these challenging requirements and achieve the successful performance of implants. In this study, we proposed a substrate surface-modification strategy based on biofilm CsgA proteins that promote rapid cell attachment, proliferation, and stabilization of the cytoskeleton. CsgA-based nano-coating is easy to fabricate and has superior performance, which is expected to expand the application of medical implants.
- Biocompatibility,
- CsgA,
- Fractal-like morphologies,
- Nanocoatings,
- Wound healing
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