Citation: Xinru You, Liying Wang, Junfu Zhang, Tong Tong, Chunlei Dai, Chun Chen, Jun Wu. Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy[J]. Chinese Chemical Letters, ;2023, 34(4): 107720. doi: 10.1016/j.cclet.2022.07.063 shu

Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy

Xinru You ^{a, b} ,
Liying Wang ^b ,
Junfu Zhang ^c ,
Tong Tong ^b ,
Chunlei Dai ^b ,
Chun Chen ^{a, *,} ,
Jun Wu ^{a, b, *,}

a.
Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China
b.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518057, China
c.
Department of Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China

chenchun69@126.com

wujun29@mail.sysu.edu.cn

Received Date: 14 May 2022
Revised Date: 23 July 2022
Accepted Date: 27 July 2022
Available Online: 2 August 2022

Figures(7)

The clinical efficacy of chemotherapeutic drugs is hindered by their poor aqueous solubility, low bioavailability and severe side effects. In recent years, polymeric nanocarriers have been used for drug delivery to improve the efficacy of many chemotherapeutics. In this study, a series of biodegradable phenylalanine-based poly(ester amide) (Phe-PEA) with tunable molecular weights (MWs) were synthesized to systematically investigate the relationship between the polymer MW and the efficacy of the corresponding polymeric nanoparticles (NPs). The results indicated that a range of polymers with different MWs can be obtained by varying the monomer ratio or reaction time. Doxorubicin (DOX), a classic clinical lymphoma treatment strategy, was selected as a model drug. The loading capacity and stability of the higher MW polymeric NPs were superior to those of the lower MW ones. Moreover, in vitro and in vivo data revealed that high MW polymeric NPs had better anticancer efficacy against lymphoma and higher biosafety than low MW polymeric nanoparticles and DOX. Therefore, this study suggests the importance of polymer MW for drug delivery systems and provides valuable guidance for the design of enhanced polymeric drug carriers for lymphoma treatment.
- Nanoparticles,
- Drug delivery,
- Lymphoma therapy,
- Polymer molecular weight,
- Poly(ester amide)
1. [1]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA A Cancer J. Clin. 71 (2021) 209–249. doi: 10.3322/caac.21660
2. [2]
  J.S. O'Donnell, E.P. Hoefsmit, M.J. Smyth, C.U. Blank, M.W.L. Teng, Clin. Cancer Res. 25 (2019) 5743–5751. doi: 10.1158/1078-0432.CCR-18-2641
3. [3]
  S.P. Pitroda, S.J. Chmura, R.R. Weichselbaum, Lancet Oncol. 20 (2019) e434–e442. doi: 10.1016/S1470-2045(19)30157-3
4. [4]
  G. Bocci, R.S. Kerbel, Nat. Rev. Clin. Oncol. 13 (2016) 659–673. doi: 10.1038/nrclinonc.2016.64
5. [5]
  V.T. DeVita, E. Chu, Cancer Res. 68 (2008) 8643. doi: 10.1158/0008-5472.CAN-07-6611
6. [6]
  S. Mitragotri, P.A. Burke, R. Langer, Nat. Rev. Drug Discov. 13 (2014) 655. doi: 10.1038/nrd4363
7. [7]
  T. Souho, L. Lamboni, L. Xiao, G. Yang, Biotechnol. Adv. 36 (2018) 1928–1945. doi: 10.1016/j.biotechadv.2018.08.001
8. [8]
  I. de Lazaro, D.J. Mooney, Nat. Mater. 20 (2021) 1469–1479. doi: 10.1038/s41563-021-01047-7
9. [9]
  L. Fang, Z. Zhao, J. Wang, et al., Acta Pharm. Sin. B B 12 (2022) 353–363. doi: 10.1016/j.apsb.2021.06.006
10. [10]
  Y. Qu, B. Chu, X. Wei, et al., J. Control. Release 296 (2019) 93–106. doi: 10.1016/j.jconrel.2019.01.016
11. [11]
  M. Elsabahy, G.S. Heo, S.M. Lim, G. Sun, K.L. Wooley, Chem. Rev. 115 (2015) 10967–11011. doi: 10.1021/acs.chemrev.5b00135
12. [12]
  X. You, Y. Kang, G. Hollett, et al., J. Mater. Chem. B 4 (2016) 7779–7792. doi: 10.1039/C6TB01925K
13. [13]
  Y. Cui, T. Zhu, X. Zhang, et al., Chin. Chem. Lett. 33 (2022) 4617–4622. doi: 10.1016/j.cclet.2022.03.077
14. [14]
  B. Chu, Y. Qu, X. He, et al., Adv. Funct. Mater. 30 (2020) 2005918. doi: 10.1002/adfm.202005918
15. [15]
  H. Guo, F. Li, H. Qiu, et al., Research 2020 (2020) 8970135.
16. [16]
  Z. Zhao, A. Ukidve, V. Krishnan, S. Mitragotri, Adv. Drug Deliv. Rev. 143 (2019) 3–21. doi: 10.1016/j.addr.2019.01.002
17. [17]
  A. Bernkop-Schnürch, Adv. Drug Deliv. Rev. 136-137 (2018) 62–72.
18. [18]
  X. Zheng, J. Xie, X. Zhang, et al., Chin. Chem. Lett. 32 (2021) 243–257. doi: 10.1016/j.cclet.2020.11.029
19. [19]
  N. Kamaly, B. Yameen, J. Wu, O.C. Farokhzad, Chem. Rev. 116 (2016) 2602–2663. doi: 10.1021/acs.chemrev.5b00346
20. [20]
  Y. Wang, J. Wang, D. Zhu, et al., Acta Pharm. Sin. B 11 (2021) 886–902. doi: 10.1016/j.apsb.2021.03.007
21. [21]
  S. Arpicco, M. Bartkowski, A. Barge, et al., Front. Chem. 8 (2020) 578008. doi: 10.3389/fchem.2020.578008
22. [22]
  J.E. Dahlman, C. Barnes, O.F. Khan, et al., Nat. Nanotechnol. 9 (2014) 648–655. doi: 10.1038/nnano.2014.84
23. [23]
  M.M. Abdelghafour, Á. Orbán, Á. Deák, et al., Int. J. Pharm. 618 (2022) 121653. doi: 10.1016/j.ijpharm.2022.121653
24. [24]
  G. Li, S. He, A.G. Schätzlein, et al., J. Control. Release 332 (2021) 210–224. doi: 10.1016/j.jconrel.2021.02.007
25. [25]
  U. Capasso Palmiero, M. Maraldi, N. Manfredini, D. Moscatelli, Biomacromolecules 19 (2018) 1314–1323. doi: 10.1021/acs.biomac.8b00127
26. [26]
  H. Liu, S.S. Venkatraman, J. Pharm. Sci. 103 (2014) 485–495. doi: 10.1002/jps.23790
27. [27]
  D. Lou, X. Lu, M. Zhang, M. Bai, J. Jiang, Chem. Commun. 54 (2018) 6987–6990. doi: 10.1039/C8CC01184B
28. [28]
  X. You, Z. Gu, J. Huang, et al., Acta Biomater. 74 (2018) 180–191. doi: 10.1016/j.actbio.2018.05.040
29. [29]
  M. Rhee, P.M. Valencia, M.I. Rodriguez, et al., Adv. Mater. 23 (2011) H79–H83. doi: 10.1002/adma.201004333
30. [30]
  J. Wu, C.C. Chu, J. Mater. Chem. B 1 (2013) 353–360. doi: 10.1039/C2TB00070A
31. [31]
  J. Wu, C.C. Chu, Acta Biomater. 8 (2012) 4314–4323. doi: 10.1016/j.actbio.2012.07.027
1. [1]
  Lian Jin , Juan Zhang , Libo Nie , Yan Deng , Ghulam Jilany Khana , Nongyue He . Chitosan nanoparticles act as promising carriers of microRNAs to brain cells in neurodegenerative diseases. Chinese Chemical Letters, 2025, 36(10): 110774-. doi: 10.1016/j.cclet.2024.110774
2. [2]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
3. [3]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
4. [4]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
5. [5]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
6. [6]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
7. [7]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
8. [8]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
9. [9]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
10. [10]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
11. [11]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
12. [12]
  Liangyu Zhang , Lei Lei , Zhuangzhuang Zhao , Guizhi Yang , Kaitao Wang , Liying Wang , Ningxin Zhang , Yanjia Ai , Xinqing Ma , Guannan Liu , Meng Zhao , Jun Wu , Dongjun Lin , Chun Chen . Enhanced venetoclax delivery using l-phenylalanine nanocarriers in acute myeloid leukemia treatment. Chinese Chemical Letters, 2025, 36(6): 110316-. doi: 10.1016/j.cclet.2024.110316
13. [13]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
14. [14]
  Fereshte Hassanzadeh-Afruzi , Mina Azizi , Iman Zare , Ehsan Nazarzadeh Zare , Anwarul Hasan , Siavash Iravani , Pooyan Makvandi , Yi Xu . Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing. Chinese Chemical Letters, 2024, 35(11): 109564-. doi: 10.1016/j.cclet.2024.109564
15. [15]
  Han Wu , Yumei Wang , Zekai Ren , Hailin Cong , Youqing Shen , Bing Yu . The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy. Chinese Chemical Letters, 2025, 36(4): 109996-. doi: 10.1016/j.cclet.2024.109996
16. [16]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
17. [17]
  Tianxia Chen , Yunhui Chen , Weiwei Li , Peipei Cen , Yan Guo , Jin Zhang , Cunding Kong , Xiangyu Liu . Fabricating AuAg-nanoparticles/ZIF-8 composites for selective detection and efficient extraction of dinitroaniline pesticides. Chinese Chemical Letters, 2025, 36(8): 110214-. doi: 10.1016/j.cclet.2024.110214
18. [18]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
19. [19]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
20. [20]
  Haotian Shi , Yuchao Luo , Song Zhang , Meijun Zhao , Chaoyong Liu , Qing Pei , Helei Wang , Qiong Dai , Zhigang Xie , Bin Xu , Wenjing Tian . Dual-responsive nanogels with high drug loading for enhanced tumor targeting and treatment. Chinese Chemical Letters, 2025, 36(10): 110775-. doi: 10.1016/j.cclet.2024.110775

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(1273)
HTML views(167)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142