Citation: Ning Guo, Yu Xia, Yuxi Duan, Quanxin Wu, Le Xiao, Yaxin Shi, Bin Yang, Yun Liu. Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy[J]. Chinese Chemical Letters, ;2023, 34(2): 107542. doi: 10.1016/j.cclet.2022.05.056 shu

Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy

Ning Guo ^a ,
Yu Xia ^a ,
Yuxi Duan ^a ,
Quanxin Wu ^a ,
Le Xiao ^a ,
Yaxin Shi ^a ,
Bin Yang ^{b, *,} ,
Yun Liu ^{a, c, *,}

a.
Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China
b.
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
c.
The Marine Biomedical Research Institute of Guangdong, Zhanjiang 524023, China

bin.yang@gzhmu.edu.cn

liuyun_2017@hotmail.com

Received Date: 27 January 2022
Revised Date: 13 May 2022
Accepted Date: 17 May 2022
Available Online: 21 May 2022

Figures(5)

Cu_2-xS nanostructures have been intensively studied as outstanding chemodynamic therapy (CDT) and good photothermal therapy (PTT) antibacterial agents due to their highly efficient Cu(Ⅰ)-initiated Fenton-like catalytic activity and good photothermal conversion property. However, they still suffer from shortage of Cu(Ⅰ) supply in the long-term and comparatively low inherent photothermal conversion efficiency. Herein, we constructed a self-enhanced synergistic PTT/CDT nanoplatform (Cu_1.94S@MPN) by coating Cu_1.94S nanoparticles with Fe(Ⅲ)/tannic acid based metal-polyphenol networks (MPN). Activated by the acidic bacterial infection microenvironment, Cu_1.94S@MPN could be decomposed to continuously release Cu(Ⅱ), Fe(Ⅲ) ions and tannic acid. As the result of tannic acid-involved Cu and Fe redox cycling, Cu(Ⅰ)/Fe(Ⅱ)-rich CDT could be achieved through the highly accelerated catalytic Fenton/Fenton-like reactions. More importantly, experimental results demonstrated that Cu_1.94S@MPN exhibited both excellent photothermal antibacterial and photothermal-enhanced CDT properties to eradicate bacteria in vitro and in vivo. Overall, this novel nanotherapeutics has great potential to become a clinic candidate for anti-infective therapy in future.
- Antibacterial,
- Self-enhanced,
- Photothermal therapy,
- Chemodynamic therapy,
- Anti-infective therapy
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