Citation: Shushuai Chen, Hongxin Liu, Saini Li, Yuchan Chen, Wei Ye, Haohua Li, Haibo Tan, Dongli Li, Zhaoming Liu, Weimin Zhang. Hawanoids A‒E, unprecedented diterpenoids with PAF-induced platelet aggregation inhibitory activities from the deep-sea-derived fungus Paraconiothyrium hawaiiense[J]. Chinese Chemical Letters, ;2023, 34(2): 107513. doi: 10.1016/j.cclet.2022.05.027 shu

Hawanoids A‒E, unprecedented diterpenoids with PAF-induced platelet aggregation inhibitory activities from the deep-sea-derived fungus Paraconiothyrium hawaiiense

Shushuai Chen ^{a, b, 1} ,
Hongxin Liu ^{a, 1} ,
Saini Li ^a ,
Yuchan Chen ^a ,
Wei Ye ^a ,
Haohua Li ^a ,
Haibo Tan ^c ,
Dongli Li ^b ,
Zhaoming Liu ^{a, *,} ,
Weimin Zhang ^{a, *,}

a.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China
b.
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
c.
Program for Natural Product Chemical Biology, Key Laboratory Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

liuzm@gdim.cn

wmzhang@gdim.cn

Received Date: 18 February 2022
Revised Date: 7 May 2022
Accepted Date: 11 May 2022
Available Online: 14 May 2022

Figures(4)

Hawanoids A‒E (1‒5), five highly cyclized diterpenoids were isolated from the deep-sea-derived fungus Paraconiothyrium hawaiiense FS482. Compounds 1 and 2 possessed an unprecedented tetracyclo[6.6.2.0^2,7.0^11,15]cetane carbon skeleton while 3 and 4 possessed an unusual 11, 14-macrocyclic ether moiety in phomactin family. Their structures including the stereo-chemistry were determined through spectroscopic analysis, X-ray diffractions and computational calculations. The plausible biosynthetic pathway was proposed based on the predicted biosynthetic gene cluster. All of the isolated compounds exhibited inhibitory activities against PAF-induced platelet aggregation. The molecular docking study was carried out understand the interaction between the PAF receptor and hawanoids with different skeletons.
- Diterpenoids,
- Deep-sea-derived fungus,
- Biosynthetic pathway,
- Platelet aggregation inhibition,
- Molecular docking
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沈阳化工大学材料科学与工程学院沈阳 110142