Citation: Tianqi Wang, Yanan Fu, Shengjie Sun, Chenyi Huang, Yunfei Yi, Junqing Wang, Yang Deng, Meiying Wu. Exosome-based drug delivery systems in cancer therapy[J]. Chinese Chemical Letters, ;2023, 34(2): 107508. doi: 10.1016/j.cclet.2022.05.022 shu

Exosome-based drug delivery systems in cancer therapy

School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China

wangjunqing@mail.sysu.edu.cn

dengy67@mail.sysu.edu.cn

wumy53@mail.sysu.edu.cn

Received Date: 20 January 2022
Revised Date: 6 May 2022
Accepted Date: 10 May 2022
Available Online: 14 May 2022

Figures(4)

Exosome, which is a kind of extracellular vesicles with size around 40-160 nm, plays an important role in cell-to-cell communication in multiple diseases. Especially in tumor microenvironment, exosomes are the important pathway to transit proteins, nucleic acids and small molecules between different kinds of cells. Based on these characteristics, exosomes are served as both therapeutic agents and drug delivery systems in cancer therapy. In this review, the applications of exosomes as drug delivery systems in cancer therapy were summarized and classified according to the cell source of the exosomes, including normal cells, immune cells and tumor cells. Different modifications of exosomes and drug loading methods were presented. Finally, some challenges that hindered the clinical translation of exosomes were also discussed.
- Exosome,
- Drug delivery,
- Cancer therapy,
- Immunotherapy,
- Macrophages,
- Tumor cells
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沈阳化工大学材料科学与工程学院沈阳 110142