Citation: George Frimpong Boafo, Yejiao Shi, Qingqing Xiao, Kosheli Thapar Magar, Makhloufi Zoulikha, Xuyang Xing, Chao Teng, Emmanuel Brobbey, Xiaotong Li, Xiaohong Jiang, Xiaochun Wang, Yi Yang, Samuel Kesse, Wei He. Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes[J]. Chinese Chemical Letters, ;2022, 33(10): 4600-4604. doi: 10.1016/j.cclet.2022.04.033 shu

Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes

George Frimpong Boafo ^{a, b, 1} ,
Yejiao Shi ^{c, 1} ,
Qingqing Xiao ^{b, 1} ,
Kosheli Thapar Magar ^b ,
Makhloufi Zoulikha ^b ,
Xuyang Xing ^a ,
Chao Teng ^b ,
Emmanuel Brobbey ^b ,
Xiaotong Li ^b ,
Xiaohong Jiang ^b ,
Xiaochun Wang ^b ,
Yi Yang ^b ,
Samuel Kesse ^c ,
Wei He ^{a, b, *,}

a.
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China
b.
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
c.
Institute of Translation Medicine, Shanghai University, Shanghai 200444, China

weihe@cpu.edu.cn

Received Date: 18 November 2021
Revised Date: 10 April 2022
Accepted Date: 11 April 2022
Available Online: 17 April 2022

Figures(5)

Breast cancer is the most prevalent cancer in women, and it was hard to prevent or diagnose at an early stage. Thus, it is imperative to develop advanced therapeutics for effective treatment. Herein, a targeted daunorubicin (DNR) and cytarabine (ara-C) co-delivery system was developed by modifying the ara-C loaded liposomes (LIP-ara-C) with the hyaluronic acid-DNR (HA-DNR) prodrugs. The co-assembled hybrid nanoparticles (HA-DNR/LIP-ara-C HNPs) exhibited good serum and storage stability with an average diameter of approximately 100 nm. By specifically binding to the CD44 receptors that overexpressed on cancer cells, these HNPs could be uptake via endocytosis and accumulate intracellularly, in which an optimized DNR and ara-C combination at a molar ratio of 1:5 could generate enhanced synergistic effects with reduced dose-related toxicity on cancer cells.
- Breast cancer,
- Daunorubicin,
- Cytarabine,
- Co-delivery,
- Liposomes
1. [1]
  F. Bray, J. Ferlay, I. Soerjomataram, et al., CA-Cancer J. Clin.68 (2018) 394-424. doi: 10.3322/caac.21492
2. [2]
  R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, CA Cancer J. Clin. 72 (2022) 7-33. doi: 10.3322/caac.21708
3. [3]
  A.G. Waks, E.P. Winer, JAMA 321 (2019) 288-300. doi: 10.1001/jama.2018.19323
4. [4]
  H. Joshi, M.F. Press, 22 - Molecular oncology of breast cancer, in: K.I. Bland, E.M. Copeland, V.S. Klimberg, W.J. Gradishar (Eds. ), The Breast, Elsevier, Amsterdam, 2018, pp. 282-307. e5
5. [5]
  M. Piccart-Gebhart, M. Procter, B. Leyland-Jones, et al., N. Engl. J. Med. 353 (2005) 1659-1672. doi: 10.1056/NEJMoa052306
6. [6]
  C. Denkert, C. Liedtke, A. Tutt, G. von Minckwitz, The Lancet 389 (2017) 2430-2442. doi: 10.1016/S0140-6736(16)32454-0
7. [7]
  M. Chavez-MacGregor, E.A. Mittendorf, C.A. Clarke, et al., Oncologist 22 (2017) 1292. doi: 10.1634/theoncologist.2017-0116
8. [8]
  A. Bardia, I.A. Mayer, J.R. Diamond, et al., J. Clin. Oncol. 35 (2017) 2141. doi: 10.1200/JCO.2016.70.8297
9. [9]
  S.M. Swain, J. Baselga, S.B. Kim, et al., N. Engl. J. Med. 372 (2015) 724-734. doi: 10.1056/NEJMoa1413513
10. [10]
  J.F. Robertson, J.P. Lindemann, A. Llombart-Cussac, et al., Breast Cancer Res. Tr. 136 (2012) 503-511. doi: 10.1007/s10549-012-2192-4
11. [11]
  B. Löwenberg, G.J. Ossenkoppele, W. van Putten, et al., New Engl. J. Med. 361 (2009) 1235-1248. doi: 10.1056/NEJMoa0901409
12. [12]
  R.L. Momparler, Exp. Hematol. Oncol. 2 (2013) 1-5. doi: 10.1186/2162-3619-2-1
13. [13]
  J.E. Lancet, G.L. Uy, J.E. Cortes, et al., J. Clin. Oncol. 36 (2018) 2684. doi: 10.1200/jco.2017.77.6112
14. [14]
  W. Wu, Y. Lu, J. Qi, Ther. Deliv. 6 (2015) 1239-1241. doi: 10.4155/tde.15.69
15. [15]
  W. He, X. Xing, X. Wang, et al., Adv. Funct. Mater. 30 (2020) 1910566. doi: 10.1002/adfm.201910566
16. [16]
  R. Quere, S. Andradottir, A. Brun, et al., Leukemia 25 (2011) 515-526. doi: 10.1038/leu.2010.281
17. [17]
  W. Li, C. Zhou, Y. Fu, et al., Acta Pharma. Sin. B 10 (2020) 693-710. doi: 10.1016/j.apsb.2019.07.003
18. [18]
  Y. Luo, G.D. Prestwich, Bioconjugate Chem. 10 (1999) 755-763. doi: 10.1021/bc9900338
19. [19]
  W. Liu, D. Li, Z. Dong, et al., Int. J. Pharm. 587 (2020) 119682. doi: 10.1016/j.ijpharm.2020.119682
20. [20]
  Y. Lv, C. Xu, X. Zhao, et al., ACS Nano 12 (2018) 1519-1536. doi: 10.1021/acsnano.7b08051
21. [21]
  B.A. Carneiro, W.S. El-Deiry, Nat. Rev. Clin. Oncol. 17 (2020) 395-417. doi: 10.1038/s41571-020-0341-y
22. [22]
  A. Arouri, A.H. Hansen, T.E. Rasmussen, O.G. Mouritsen, Curr. Opin. Colloid Interface Sci. 18 (2013) 419-431. doi: 10.1016/j.cocis.2013.06.001
1. [1]
  Yunjie Dang , Yanru Feng , Xiao Chen , Chaoxing He , Shujie Wei , Dingyang Liu , Jinlong Qi , Huaxing Zhang , Shaokun Yang , Zhiyun Niu , Bai Xiang . Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of siRNA and small-molecule drugs in tumor treatment. Chinese Chemical Letters, 2024, 35(12): 109660-. doi: 10.1016/j.cclet.2024.109660
2. [2]
  Keqiang Shi , Xiujuan Hong , Dongyan Xu , Tao Pan , Huiwen Wang , Hongru Feng , Cheng Guo , Yuanjiang Pan . Analysis of RNA modifications in peripheral white blood cells from breast cancer patients by mass spectrometry. Chinese Chemical Letters, 2025, 36(3): 110079-. doi: 10.1016/j.cclet.2024.110079
3. [3]
  Xinyue Han , Yunhan Yang , Jiayin Lu , Yuxiang Lin , Dongxue Zhang , Ling Lin , Liang Qiao . Efficient serum lipids profiling by TiO₂-dopamin-assisted MALDI-TOF MS for breast cancer detection. Chinese Chemical Letters, 2025, 36(5): 110183-. doi: 10.1016/j.cclet.2024.110183
4. [4]
  Hongyi Huang , Siyao Che , Wenjie Zhou , Yunchu Zhang , Weiling Zhuo , Xijing Yang , Songping Zheng , Jiagang Liu , Xiang Gao . Apatinib potentiates doxorubicin with cRGD-functionalized pH-sensitive micelles against glioma. Chinese Chemical Letters, 2025, 36(5): 110084-. doi: 10.1016/j.cclet.2024.110084
5. [5]
  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
6. [6]
  Jialin Xie , Qing Feng , Zhen Li , Jinyi Yang , Min Liu , Wei Qi . Life’s Guardian Angel: Progesterone. University Chemistry, 2024, 39(10): 416-419. doi: 10.12461/PKU.DXHX202403068
7. [7]
  Li Fu , Ziye Su , Shuyang Wu , Yanfen Cheng , Chuan Hu , Jinming Zhang . Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy. Chinese Chemical Letters, 2025, 36(5): 110227-. doi: 10.1016/j.cclet.2024.110227
8. [8]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
9. [9]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
10. [10]
  Honghao Sun , Huimin Zhao , Ronghui Yin , Chenxi Zhou , Ming Wu , Yueyang Deng , Zhanwei Zhou , Minjie Sun . Injectable hydrogel-based tumor vaccine with fibrotic tumor immune microenvironment remodeling to prevent breast cancer postoperative recurrence and metastases. Chinese Chemical Letters, 2025, 36(5): 110067-. doi: 10.1016/j.cclet.2024.110067
11. [11]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
12. [12]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
13. [13]
  Wenping Dong , Mo Ma , Jingkang Li , Lanlan Xu , Dejiang Gao , Pinyi Ma , Daqian Song . Near-infrared fluorescent probe with large Stokes shift and long emission wavelength for rapid diagnosis of lung cancer via aerosol inhalation delivery. Chinese Chemical Letters, 2025, 36(5): 110147-. doi: 10.1016/j.cclet.2024.110147
14. [14]
  Kun Chen , Huimin Lin , Xin Peng , Ziying Wu , Jingyue Dai , Yi Sun , Yaxuan Feng , Ziyi Huang , Zhiqiang Yu , Meng Yu , Guangyu Yao , Jigang Wang . In situ synthesis of MnO₂ micro/nano-adjuvants for enhanced immunotherapy of breast tumors. Chinese Chemical Letters, 2025, 36(5): 110045-. doi: 10.1016/j.cclet.2024.110045
15. [15]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
16. [16]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
17. [17]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
18. [18]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
19. [19]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
20. [20]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724

Get Citation

PDF

XML

Metrics

PDF Downloads(14)
Abstract views(774)
HTML views(75)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142