Citation: Danhua Ge, Jia-Wei Chen, Pei Xu, Jinyin Pan, Xue-Qiang Chu. 1,n-Thiosulfonylation using thiosulfonates as dual functional reagents[J]. Chinese Chemical Letters, ;2022, 33(11): 4732-4739. doi: 10.1016/j.cclet.2022.02.019 shu

1,n-Thiosulfonylation using thiosulfonates as dual functional reagents

Danhua Ge ^a ,
Jia-Wei Chen ^a ,
Pei Xu ^{b, *,} ,
Jinyin Pan ^c ,
Xue-Qiang Chu ^{a, *,}

a.
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
b.
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
c.
Sartorius Stedim (Shanghai) Trading Co., Ltd., Shanghai 200000, China

xupei@xzhmu.edu.cn

xueqiangchu@njtech.edu.cn

Received Date: 10 December 2021
Revised Date: 8 February 2022
Accepted Date: 10 February 2022
Available Online: 15 February 2022

Figures(17)

In recent years, the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the diverse synthesis of important S-containing derivatives. These 1,n-thiosulfonylation reactions usually feature simple procedures, 100% atom economy, and high regioselectivity. This review focuses on the recent advancements in the transformations of thiosulfonates through 1,n-thiosulfonylation involving the formation of two distinct C-S bonds under transition-metal-catalyzed or metal-free conditions, where thiosulfonates act as both a sulfonyl and a sulfenyl component.
- Thiosulfonylation,
- Thiosulfonates,
- Dual functional reagents,
- Difunctionalization,
- Atomic economy
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