Citation: Shaohua Zhang, Hang Zhou, Chang Huang, Jianguo Sun, Xue Qu, Yi Lu. A novel corneal adhesive based on functionally coupled PEG-lysozyme hydrogel for wound closure after surgical eye surgery[J]. Chinese Chemical Letters, ;2022, 33(9): 4321-4325. doi: 10.1016/j.cclet.2022.01.024 shu

A novel corneal adhesive based on functionally coupled PEG-lysozyme hydrogel for wound closure after surgical eye surgery

Shaohua Zhang ^{a, 1} ,
Hang Zhou ^{b, 1} ,
Chang Huang ^a ,
Jianguo Sun ^{a, *,} ,
Xue Qu ^{b, *,} ,
Yi Lu ^{a, *,}

a.
Eye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Fudan University, Shanghai 200031, China
b.
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

jgsun@fudan.edu.cn

quxue@ecust.edu.cn

luyieent@126.com

Received Date: 28 October 2021
Revised Date: 11 January 2022
Accepted Date: 11 January 2022
Available Online: 16 January 2022

Figures(7)

Corneal wound closure for surgical eye surgeries or accidents is typically performed to prevent pathogens from the sterile intraocular environment and avoid potential postoperative complications. Tissue adhesives are increasingly employed for corneal wound closure with superior treatment efficiency and less adverse effects. In this study, we successfully develop a novel corneal adhesive based on functionally coupled PEG-lysozyme (PEG-LZ) hydrogels for wound closure after surgical eye surgeries. PEG-LZ hydrogels have plenty of micropores and gradually decreased pore size with increasing concentration from 10%, 15% to 20% (w/v), in which PEG-LZ (15%) represents the suitable pH value, gelation time and elastic modulus. PEG-LZ hydrogels have no in vitro cytotoxicity and excellent ex vivo wound closure effectiveness in porcine eyes. The in vivo wound sealant in rabbit eyes by PEG-LZ hydrogels presents a superior therapeutic effect compared with the conventional methods of stromal hydration and suture, in terms of the wound closure percent, mean corneal thickness, percent of wound gaping, and the Descemet membrane detachment. PEG-LZ hydrogels do not induce obvious histological pathology changes. The PEG-LZ corneal adhesive is considered as a tissue adhesive alternative for wound closure after surgical eye surgeries.
- Corneal adhesive,
- Hydrogel,
- Wound closure,
- Polyethylene glycol (PEG),
- Lysozyme
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