Citation: Juan Qiao, Xiangfei Li, Li Qi. Fluorescent polymer-modified gold nanobipyramids for temperature sensing during photothermal therapy in living cells[J]. Chinese Chemical Letters, ;2022, 33(6): 3193-3196. doi: 10.1016/j.cclet.2021.12.070 shu

Fluorescent polymer-modified gold nanobipyramids for temperature sensing during photothermal therapy in living cells

Juan Qiao ^{a, b} ,
Xiangfei Li ^{a, c} ,
Li Qi ^{a, b, *}

a.
Beijing National Laboratory of Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
c.
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China

qili@iccas.ac.cn

Received Date: 6 September 2021
Revised Date: 4 November 2021
Accepted Date: 26 December 2021
Available Online: 1 January 2022

Figures(7)

The temperature monitoring of treated cancer cells is critical in photothermal therapy. Current methods of detecting intracellular temperatures have low accuracy and poor spatial resolution, which limits their application to photothermal therapy. Herein, a strategy for targeted recognition and selective capture of MCF-7 breast cancer cells based on fluorescent polymer poly(N-isopropylacrylamide-benzoxadiazole-2-vinyl-4,4-dimethyl azlactone, PNMV) and modified gold nanobipyramids (AuNBPs-PNMV) was developed for temperature sensing during photothermal therapy. A mucin-1 protein aptamer (Apt) was applied to selectively target mucin-1 protein overexpressed on the surfaces of the MCF-7 cells, which can reduce interference by affinity interaction between the Apt and proteins. During photothermal therapy, the significant AuNBPs photothermal effect increases the fluorescence intensity of PNMV with temperature. Irradiation of MCF-7 cells cultured with AuNBPs-PNMV@Apt by an 808 nm laser increases the temperature of the system, while the cells can be inactivated because of the remarkable AuNBPs-PNMV@Apt photothermal effect. The results indicate that variation in the fluorescence of AuNBPs-PNMV@Apt can be applied as thermometers to monitor the intracellular effect of photothermal therapy.
- Fluorescent polymer,
- Gold nanobipyramids,
- Temperature monitoring,
- Photothermal therapy
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