Citation: Tianyu Chen, Dexuan Xiao, Yanjing Li, Sirong Shi, Xiao Yang, Shuanglin Peng, Bin Guo, Xiaoxiao Cai. Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells[J]. Chinese Chemical Letters, ;2022, 33(5): 2517-2521. doi: 10.1016/j.cclet.2021.11.090 shu

Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells

Tianyu Chen ^a ,
Dexuan Xiao ^a ,
Yanjing Li ^a ,
Sirong Shi ^a ,
Xiao Yang ^a ,
Shuanglin Peng ^a ,
Bin Guo ^{b, *,} ,
Xiaoxiao Cai ^{a, *,}

a.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
Department of Stomatology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

guobin0408@126.com

xcai@scu.edu.cn

Received Date: 29 September 2021
Revised Date: 26 November 2021
Accepted Date: 30 November 2021
Available Online: 4 December 2021
Fund Project: the National Key R & D Program of China 2019YFA0110600National Natural Science Foundation of China 82171006National Natural Science Foundation of China 81970986National Natural Science Foundation of China 81771125National Natural Science Foundation of China 82001432West China Hospital Postdoctoral Science Foundation 2020HXBH104

Figures(4)

Osteoporosis (OP) is a noncommunicable bone disease caused by a shift in the balance between osteoblasts and osteoclasts, and can severely affect the health of elderly persons. Autologous stem-cell transplantation can improve reduced bone density and weakened fracture healing abilities in patients with OP. However, OP can adversely affect the osteogenesis and proliferation abilities of autologous adipose-derived stem cells (ASCs). Therefore, an effective drug is required to facilitate autologous ASCs to recover their osteogenic and proliferative potential. Tetrahedral framework nucleic acid (tFNA) is a new type of nanomaterial that has ability to regulate the biological behavior of cells effectively and enhance the bioactivity of stem cells. In this study, we examine the effects of tFNAs on the osteogenic differentiation and proliferation abilities of ASCs in rats with OP. The results indicate that the 250 nmol/L tFNAs can considerably increase the expression of osteogenesis-related markers, effectively promote the proliferation and osteogenic differentiation of osteoporotic ASCs (OP-ASCs), and help them to regain their osteogenic and proliferative potential. In short, tFNAs can enable OP-ACSs to recover their osteogenic potential and promote their proliferation and, therefore, can play a key regulatory role in autologous ASC transplantation.
- Osteoporosis,
- Tetrahedral framework nucleic acid,
- Adipose-derived stem cell,
- Autologous stem-cell transplantation,
- Osteogenic differentiation
1. [1]
  S. Das, J.C. Crockett, Drug Des. Devel. Ther. 7(2013) 435-448.
2. [2]
  L.G. Raisz, J. Clin. Invest. 115(2005) 3318-3325. doi: 10.1172/JCI27071
3. [3]
  S. Amin, S.J. Achenbach, E.J. Atkinson, S. Khosla, L.J. Melton, J. Bone Miner. Res. 29(2014) 581-589. doi: 10.1002/jbmr.2072
4. [4]
  S.R. Cummings, L.J. Melton, Lancet 359(2002) 1761-1767. doi: 10.1016/S0140-6736(02)08657-9
5. [5]
  D.M. Black, C.J. Rosen, N. Engl. J. Med. 374(2016) 254-262. doi: 10.1056/NEJMcp1513724
6. [6]
  S. Li, Y. Liu, T. Tian, et al., Small 17(2021) 2104359. doi: 10.1002/smll.202104359
7. [7]
  K. Huang, G. Liu, Z. Gu, J. Wu, Chin. Chem. Lett. 31(2020) 3190-3194. doi: 10.1016/j.cclet.2020.07.002
8. [8]
  Q. Yuan, J. Huang, C. Xian, J. Wu, ACS Appl. Mater. Inter. 13(2021) 2165-2178. doi: 10.1021/acsami.0c15133
9. [9]
  S. Khosla, L.C. Hofbauer, Lancet Diabetes Endo. 5(2017) 898-907. doi: 10.1016/S2213-8587(17)30188-2
10. [10]
  F. Cosman, D.B. Crittenden, J.D. Adachi, et al., N. Engl. J. Med. 375(2016) 1532-1543. doi: 10.1056/NEJMoa1607948
11. [11]
  S. Verma, J.H. Rajaratnam, J. Denton, J.A. Hoyland, R.J. Byers, J. Clin. Pathol. 55(2002) 693-698. doi: 10.1136/jcp.55.9.693
12. [12]
  H. Mizuno, M. Tobita, A.C. Uysal, Stem Cells 30(2012) 804-810. doi: 10.1002/stem.1076
13. [13]
  L. Wang, C. Huang, Q. Li, et al., Cell Prolif. 50(2017) e12328. doi: 10.1111/cpr.12328
14. [14]
  T. Zhang, T. Tian, Y. Lin, Adv. Mater. (2021), doi:10.1002/adma.202107820. doi: 10.1002/adma.202107820
15. [15]
  T. Zhang, T. Tian, R. Zhou, et al., Nat. Protoc. 15(2020) 2728-2757. doi: 10.1038/s41596-020-0355-z
16. [16]
  W. Ma, Y. Zhan, Y. Zhang, et al., Signal Transduct. Target. Ther. 6(2021) 351. doi: 10.1038/s41392-021-00727-9
17. [17]
  S. Sirong, C. Yang, T. Taoran, et al., Bone Res. 8(2020) 6. doi: 10.1038/s41413-019-0077-4
18. [18]
  W. Cui, X. Yang, X. Chen, et al., Adv. Funct. Mater. 31(2021) 2105152. doi: 10.1002/adfm.202105152
19. [19]
  J. Li, L. Xiao, N. Yan, et al., Adv. Funct. Mater. 31(2021) 2104141. doi: 10.1002/adfm.202104141
20. [20]
  M. Zhang, X. Zhang, T. Tian, et al., Bioact. Mater. 8(2022) 368-380. doi: 10.1016/j.bioactmat.2021.06.003
21. [21]
  W. Fu, L. Ma, Y. Ju, et al., Adv. Funct. Mater. 31(2021) 2101435. doi: 10.1002/adfm.202101435
22. [22]
  Y. Sun, Y. Liu, B. Zhang, et al., Bioact. Mater. 6(2021) 2281-2290. doi: 10.1016/j.bioactmat.2020.12.027
23. [23]
  Y. Li, R. Zhou, D. Xiao, et al., Chem. Eng. J. 403(2021) 126344. doi: 10.1016/j.cej.2020.126344
24. [24]
  T. Zhang, W. Cui, T. Tian, S. Shi, Y. Lin, ACS Appl. Mater. Interfaces 12(2020) 47115-47126. doi: 10.1021/acsami.0c13806
25. [25]
  E.L. Ritman, Annu. Rev. Biomed. Eng. 13(2011) 531-552. doi: 10.1146/annurev-bioeng-071910-124717
26. [26]
  J. Li, H. Pei, B. Zhu, et al., ACS Nano 5(2011) 8783-8789. doi: 10.1021/nn202774x
27. [27]
  S. Li, T. Tian, T. Zhang, X. Cai, Y. Lin, Mater. Today 24(2019) 57-68. doi: 10.1016/j.mattod.2018.08.002
28. [28]
  S. Modi, S.M. Goswami, G.D. Gupta, S. Mayor, Y. Krishnan, Nat. Nanotechnol. 4(2009) 325-330. doi: 10.1038/nnano.2009.83
29. [29]
  Y. Li, L. Wang, M. Zhang, et al., Cell Prolif. 53(2020) e12834.
30. [30]
  T. Komori, Histochem. Cell Biol. 149(2018) 313-323. doi: 10.1007/s00418-018-1640-6
31. [31]
  S.C. Moser, B.C.J. van der Eerden, Front. Endocrinol. 9(2019) 794. doi: 10.3389/fendo.2018.00794
32. [32]
  M.A. Icer, M. Gezmen-Karadag, Clin. Biochem. 59(2018) 17-24. doi: 10.1016/j.clinbiochem.2018.07.003
1. [1]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
2. [2]
  Ruijianghan Shi , Yujie Zhu , Weitong Lu , Yuhan Shao , Yang Chen , Mi Zhou , Yunfeng Lin , Sirong Shi . Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair. Chinese Chemical Letters, 2025, 36(5): 110241-. doi: 10.1016/j.cclet.2024.110241
3. [3]
  Xueyan Zhang , Jicong Chen , Songren Han , Shiyan Dong , Huan Zhang , Yuhong Man , Jie Yang , Ye Bi , Lesheng Teng . The size-switchable microspheres co-loaded with RANK siRNA and salmon calcitonin for osteoporosis therapy. Chinese Chemical Letters, 2024, 35(12): 109668-. doi: 10.1016/j.cclet.2024.109668
4. [4]
  Yanjing Li , Jiayin Li , Yuqi Chang , Yunfeng Lin , Lei Sui . Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell. Chinese Chemical Letters, 2024, 35(9): 109414-. doi: 10.1016/j.cclet.2023.109414
5. [5]
  Dexuan Xiao , Tianyu Chen , Tianxu Zhang , Sirong Shi , Mei Zhang , Xin Qin , Yunkun Liu , Longjiang Li , Yunfeng Lin . Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib. Chinese Chemical Letters, 2024, 35(4): 108602-. doi: 10.1016/j.cclet.2023.108602
6. [6]
  Yang Feng , Yang-Qing Tian , Yong-Qiang Zhao , Sheng-Jun Chen , Bi-Feng Yuan . Dynamic deformylation of 5-formylcytosine and decarboxylation of 5-carboxylcytosine during differentiation of mouse embryonic stem cells into mouse neurons. Chinese Chemical Letters, 2024, 35(11): 109656-. doi: 10.1016/j.cclet.2024.109656
7. [7]
  Kai Wang , Yun Wang , Lihang Wang , Zhuhai Li , Xi Yu , Xuanhe You , Diwei Wu , Yueming Song , Jiancheng Zeng , Zongke Zhou , Shishu Huang , Yunfeng Lin . Therapeutic siRNA targeting CC chemokine receptor 2 loaded with tetrahedral framework nucleic acid alleviates neuropathic pain by regulating microglial polarization. Chinese Chemical Letters, 2025, 36(3): 109868-. doi: 10.1016/j.cclet.2024.109868
8. [8]
  Yukun Xing , Xiaoyu Xie , Fangfang Chen . A Sunlit Gift: Vitamin D. University Chemistry, 2024, 39(9): 28-34. doi: 10.12461/PKU.DXHX202402006
9. [9]
  Yujie Zhu , Ruijianghan Shi , Weitong Lu , Yang Chen , Yunfeng Lin , Sirong Shi . Tetrahedral framework nucleic acids prevent epithelial-mesenchymal transition-mediated diabetic fibrosis by targeting the Wnt/β-catenin signaling pathway. Chinese Chemical Letters, 2025, 36(5): 110140-. doi: 10.1016/j.cclet.2024.110140
10. [10]
  Jing Guo , Zhi-Guo Lu , Rui-Chen Zhao , Bao-Ku Li , Xin Zhang . Nucleic acid therapy for metabolic-related diseases. Chinese Chemical Letters, 2025, 36(3): 109875-. doi: 10.1016/j.cclet.2024.109875
11. [11]
  Yunan Yuan , Zhimin Luo , Jie Chen , Chaoliang He , Kai Hao , Huayu Tian . Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvesting. Chinese Chemical Letters, 2024, 35(7): 109549-. doi: 10.1016/j.cclet.2024.109549
12. [12]
  Weiyu Chen , Zenghui Li , Chenguang Zhao , Lisha Zha , Junfeng Shi , Dan Yuan . Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery. Chinese Chemical Letters, 2024, 35(12): 109628-. doi: 10.1016/j.cclet.2024.109628
13. [13]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
14. [14]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
15. [15]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
16. [16]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895
17. [17]
  Zhixue Liu , Haiqi Chen , Lijuan Guo , Xinyao Sun , Zhi-Yuan Zhang , Junyi Chen , Ming Dong , Chunju Li . Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging. Chinese Chemical Letters, 2024, 35(9): 109666-. doi: 10.1016/j.cclet.2024.109666
18. [18]
  Ying Gao , Rong Zhou , Qiwen Wang , Shaolong Qi , Yuanyuan Lv , Shuang Liu , Jie Shen , Guocan Yu . Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy. Chinese Chemical Letters, 2024, 35(10): 109521-. doi: 10.1016/j.cclet.2024.109521
19. [19]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
20. [20]
  Zheyi Li , Xiaoyang Liang , Zitong Qiu , Zimeng Liu , Siyu Wang , Yue Zhou , Nan Li . Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel. Chinese Chemical Letters, 2024, 35(11): 109592-. doi: 10.1016/j.cclet.2024.109592

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(1264)
HTML views(241)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142