Citation: Hanming Dai, Zijin Cheng, Tian Zhang, Weili Wang, Jinjun Shao, Wenjun Wang, Yongxiang Zhao, Xiaochen Dong, Liping Zhong. Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy[J]. Chinese Chemical Letters, ;2022, 33(5): 2501-2506. doi: 10.1016/j.cclet.2021.11.079 shu

Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy

Hanming Dai ^{a, 1} ,
Zijin Cheng ^{a, 1} ,
Tian Zhang ^a ,
Weili Wang ^a ,
Jinjun Shao ^{a, *,} ,
Wenjun Wang ^b ,
Yongxiang Zhao ^c ,
Xiaochen Dong ^{a, *,} ,
Liping Zhong ^{c, *,}

a.
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211800, China
b.
School of Physical Science and Information Technology, Liaocheng University, Liaocheng 252059, China
c.
National Center for International Biotargeting Theranostics, Guangxi Key Laboratory of Biotargeting Theranostics, Collaborative Innovation Center for Targeting Tumor Theranostics, Guangxi Medical University, Nanning 530021, China

iamjjshao@njtech.edu.cn

iamxcdong@njtech.edu.cn

zhong_liping@163.com

Received Date: 4 October 2021
Revised Date: 23 November 2021
Accepted Date: 26 November 2021
Available Online: 1 December 2021

Figures(6)

The small molecular second near-infrared (NIR-Ⅱ, 1000-1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes. Herein, we report a novel molecular electron acceptor, boron difluoride formazanate (BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-Ⅰ absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics.
- NIR-Ⅱ nanotheranostics,
- Boron difluoride formazanate,
- Fluorescence imaging,
- Photothermal therapy,
- Phototheranostics
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