Citation: Xiang Yuan, Jianshuang Jiang, Yanan Yang, Xu Zhang, Ziming Feng, Peicheng Zhang. Three quinolizidine dimers from the seeds of Sophora alopecuroides and their hepatoprotective activities[J]. Chinese Chemical Letters, ;2022, 33(6): 2923-2927. doi: 10.1016/j.cclet.2021.10.085 shu

Three quinolizidine dimers from the seeds of Sophora alopecuroides and their hepatoprotective activities

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

pczhang@imm.ac.cn

Received Date: 31 August 2021
Revised Date: 11 October 2021
Accepted Date: 26 October 2021
Available Online: 2 November 2021

Figures(9)

Sophoralines A-C, three novel [2 + 2] cycloaddition dimers of matrine-based alkaloids with an unprecedented 6/6/6/6/4/6/6/6/6 nonacyclic skeleton containing 11 stereogenic centers, were isolated from Sophora alopecuroides. Their structures were determined by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for 1 and quantum chemical calculations of electronic circular dichroism (ECD) spectra for 2 and 3. Moreover, 1 exhibited excellent hepatoprotective activities in acetaminophen-induced liver injury in vitro and in vivo.
- Alkaloids,
- Sophora alopecuroides,
- X-ray diffraction,
- Hepatoprotective activities
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