Citation: Ke Tang, You Wu, Shubing Chen, Yijing Xin, Ying Guo. Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures[J]. Chinese Chemical Letters, ;2022, 33(5): 2541-2544. doi: 10.1016/j.cclet.2021.09.017 shu

Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures

Ke Tang ^{a, b, 1} ,
You Wu ^{a, b, 1} ,
Shubing Chen ^{a, b} ,
Yijing Xin ^{a, b} ,
Ying Guo ^{a, b, *,}

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

yingguo6@imm.ac.cn

Received Date: 6 August 2021
Revised Date: 30 August 2021
Accepted Date: 2 September 2021
Available Online: 10 September 2021

Figures(2)

In this study, SB216763 and cyclosporine A were identified as anti-influenza A virus (IAV) agents by transcriptome signature reversion (TSR) analysis through deep mining of the cellular transcriptome of human airway and lung cell lines infected with 3 strains of IAV and the chemical perturbations library. A synergistic effect of SB216763 and cyclosporine A against influenza A was disclosed by quantification of the network-based relationship, which was validated in vitro. Along with burgeoning omics approaches, transcriptome-based drug development is flourishing, which provides a novel insight into antivirals discovery with comprehensive cellular transcriptional information of disease and chemical perturbations in multicomponent intervention. This strategy can be applied as a new approach in discovering multitarget antiviral agents from approved drugs, clinical compounds, natural products or other known bioactive compounds.
- Chemical perturbagen signature,
- Host factor,
- Transcriptome signature reversion,
- Influenza A virus,
- SB216763,
- Cyclosporine A,
- Drug combination
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