Citation: Xiangling Ren, Xinyuan Huang, Qiong Wu, Longfei Tan, Changhui Fu, Yi Chen, Xianwei Meng. Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2[J]. Chinese Chemical Letters, ;2021, 32(10): 3087-3089. doi: 10.1016/j.cclet.2021.03.081 shu

Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2

Xiangling Ren ^{a, b, c, d} ,
Xinyuan Huang ^a ,
Qiong Wu ^{a, c, d} ,
Longfei Tan ^{a, c} ,
Changhui Fu ^{a, c} ,
Yi Chen ^b ,
Xianwei Meng ^{a, c, *,}

a.
Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
c.
CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
d.
University of Chinese Academy of Sciences, Beijing 100049, China

mengxw@mail.ipc.ac.cn

Received Date: 8 February 2021
Revised Date: 31 March 2021
Accepted Date: 1 April 2021
Available Online: 2 April 2021

Figures(3)

Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy. The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase (especially M2-type isozyme, PKM2), the rate limiting enzyme of glycolysis. This is helpful to the treatment of tumor. Herein, metal organic frameworks (MOFs) were found to inhibit the activity of PKM2. Nanoscale ZIF-8 was synthesized by standing and ultrasonic method, respectively. The ZIF-8 has the performance of inhibiting PKM2. Further research showed that the inhibition ability was attributed to zinc ion in ZIF-8. Interestingly, the IC₅₀ of ZIF-8 on PKM2 was one percent of that of zinc ion. This novel enzyme inhibitor is expected to be used in cancer therapy.
- Metal organic frameworks,
- Pyruvate kinase,
- Glycolysis,
- Lactate dehydrogenase,
- Inhibition
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